| http://purl.uniprot.org/citations/7984244 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7984244 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/7984244 | http://www.w3.org/2000/01/rdf-schema#comment | "The human pituitary hormones, growth hormone (hGH) and prolactin (hPRL), regulate a large variety of physiological processes, among which are growth and differentiation of muscle, bone and cartilage cells, and lactation. These activities are initiated by hormone-receptor binding. The hGH and hPRL receptors (hGHR and hPRLR, respectively) are single-pass transmembrane receptors from class 1 of the haematopoietic receptor superfamily. This classification is based on sequence similarity in their extracellular domains, notably a highly conserved pentapeptide, the so-called 'WSXWS box', the function of which is controversial. All ligands in class 1 activate their respective receptors by clustering mechanisms. In the case of hGH, activation involves receptor homodimerization in a sequential process: the active ternary complex containing one ligand and two receptor molecules is formed by association of a receptor molecule to an intermediate 1:1 complex. hPRL does not bind to the hGH receptor, but hGH binds to both the hGHR and hPRLR, and mutagenesis studies have shown that the receptor-binding sites on hGH overlap. We present here the crystal structure of the 1:1 complex of hGH bound to the extracellular domain of the hPRLR. Comparisons with the hGH-hGHR complex reveal how hGH can bind to the two distinctly different receptor binding surfaces."xsd:string |
| http://purl.uniprot.org/citations/7984244 | http://purl.org/dc/terms/identifier | "doi:10.1038/372478a0"xsd:string |
| http://purl.uniprot.org/citations/7984244 | http://purl.org/dc/terms/identifier | "doi:10.1038/372478a0"xsd:string |
| http://purl.uniprot.org/citations/7984244 | http://purl.uniprot.org/core/author | "Kossiakoff A.A."xsd:string |
| http://purl.uniprot.org/citations/7984244 | http://purl.uniprot.org/core/author | "Kossiakoff A.A."xsd:string |
| http://purl.uniprot.org/citations/7984244 | http://purl.uniprot.org/core/author | "Somers W."xsd:string |
| http://purl.uniprot.org/citations/7984244 | http://purl.uniprot.org/core/author | "Somers W."xsd:string |
| http://purl.uniprot.org/citations/7984244 | http://purl.uniprot.org/core/author | "Ultsch M."xsd:string |
| http://purl.uniprot.org/citations/7984244 | http://purl.uniprot.org/core/author | "Ultsch M."xsd:string |
| http://purl.uniprot.org/citations/7984244 | http://purl.uniprot.org/core/author | "de Vos A.M."xsd:string |
| http://purl.uniprot.org/citations/7984244 | http://purl.uniprot.org/core/author | "de Vos A.M."xsd:string |
| http://purl.uniprot.org/citations/7984244 | http://purl.uniprot.org/core/date | "1994"xsd:gYear |
| http://purl.uniprot.org/citations/7984244 | http://purl.uniprot.org/core/date | "1994"xsd:gYear |
| http://purl.uniprot.org/citations/7984244 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/7984244 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/7984244 | http://purl.uniprot.org/core/pages | "478-481"xsd:string |
| http://purl.uniprot.org/citations/7984244 | http://purl.uniprot.org/core/pages | "478-481"xsd:string |
| http://purl.uniprot.org/citations/7984244 | http://purl.uniprot.org/core/title | "The X-ray structure of a growth hormone-prolactin receptor complex."xsd:string |
| http://purl.uniprot.org/citations/7984244 | http://purl.uniprot.org/core/title | "The X-ray structure of a growth hormone-prolactin receptor complex."xsd:string |
| http://purl.uniprot.org/citations/7984244 | http://purl.uniprot.org/core/volume | "372"xsd:string |
| http://purl.uniprot.org/citations/7984244 | http://purl.uniprot.org/core/volume | "372"xsd:string |
| http://purl.uniprot.org/citations/7984244 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/7984244 |
| http://purl.uniprot.org/citations/7984244 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/7984244 |