| http://purl.uniprot.org/citations/8005444 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8005444 | http://www.w3.org/2000/01/rdf-schema#comment | "The mutational effect of the maleless (mle) gene in Drosophila has been reexamined. Earlier work had suggested that mle along with other male-lethal genes was responsible for hypertranscription of the X chromosome in males to bring about dosage compensation. Prompted by studies on dosage sensitive regulatory genes, we tested for effects of mlets on the phenotypes of 16 X or autosomal mutations in adult escapers of lethality. In third instar larvae, prior to the major lethal phase of mle, we examined activities of 6 X or autosomally encoded enzymes, steady state mRNA levels of 15 X-linked or autosomal genes and transcripts from two large genomic segments derived from either the X or from chromosome 2 and present in yeast artificial chromosomes. In contrast to the previously hypothesized role, we detected pronounced effects of mle on the expression of both X-linked and autosomal loci such that a large proportion of the tested genes were increased in expression, while only two X-linked loci were reduced. The most prevalent consequence was an increase of autosomal gene expression, which can explain previously observed reduced X:autosome transcription ratios. These observations suggest that if mle plays a role in the discrimination of the X and the autosomes, it may do so by modification of the effects of dosage sensitive regulatory genes."xsd:string |
| http://purl.uniprot.org/citations/8005444 | http://purl.org/dc/terms/identifier | "doi:10.1093/genetics/136.3.913"xsd:string |
| http://purl.uniprot.org/citations/8005444 | http://purl.uniprot.org/core/author | "Birchler J.A."xsd:string |
| http://purl.uniprot.org/citations/8005444 | http://purl.uniprot.org/core/author | "Hiebert J.C."xsd:string |
| http://purl.uniprot.org/citations/8005444 | http://purl.uniprot.org/core/date | "1994"xsd:gYear |
| http://purl.uniprot.org/citations/8005444 | http://purl.uniprot.org/core/name | "Genetics"xsd:string |
| http://purl.uniprot.org/citations/8005444 | http://purl.uniprot.org/core/pages | "913-926"xsd:string |
| http://purl.uniprot.org/citations/8005444 | http://purl.uniprot.org/core/title | "Effects of the maleless mutation on X and autosomal gene expression in Drosophila melanogaster."xsd:string |
| http://purl.uniprot.org/citations/8005444 | http://purl.uniprot.org/core/volume | "136"xsd:string |
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