| http://purl.uniprot.org/citations/8015438 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8015438 | http://www.w3.org/2000/01/rdf-schema#comment | "The Adh locus in Drosophila species which are members of the repleta group contains products of one or two duplication events. In all species examined to date one of the Adh genes is now a pseudogene, since mutations have rendered these genes incapable of being translated into a functional alcohol dehydrogenase. These pseudogenes contain introns in the standard Adh gene position; hence, their origin is not by retrotransposition. Comparison of the sequences of the Adh-psi from representatives of each of the subgroups of the repleta group reveal that the Adh pseudogene is present in each subgroup and that mutations at codon 2 and a deletion in the region immediately 5' to Adh-psi are common to all species. Therefore, it is likely that the translational inactivation event that resulted in a pseudogene occurred before the divergence of the species that make up the repleta group. We have investigated the transcription of Adh-psi of D. hydei and have found that the transcription has a developmental profile dissimilar from any known Adh gene, does not utilize an Adh promoter, and is initiated at a point almost 12 kb upstream. Comparison of sequence divergence of Adh-psi within species of the repleta group reveals that rates of evolution of the exons of Adh-psi are substantially slower than intergenic regions and are only slightly faster than those of exons of functional Adh genes. Second, retention of codon bias is found in the Adh-psi of most species, and substitution at synonymous coding positions substantially exceeds substitution at nonsynonymous coding positions. Comparison of the evolution of other putative pseudogenes with repleta group Adh pseudogenes suggests that at least some pseudogene sequences in Drosophila may be evolving through mechanisms and/or under influences not presently understood."xsd:string |
| http://purl.uniprot.org/citations/8015438 | http://purl.org/dc/terms/identifier | "doi:10.1093/oxfordjournals.molbev.a040125"xsd:string |
| http://purl.uniprot.org/citations/8015438 | http://purl.uniprot.org/core/author | "Curtiss S.W."xsd:string |
| http://purl.uniprot.org/citations/8015438 | http://purl.uniprot.org/core/author | "Menotti-Raymond M."xsd:string |
| http://purl.uniprot.org/citations/8015438 | http://purl.uniprot.org/core/author | "Starmer W.T."xsd:string |
| http://purl.uniprot.org/citations/8015438 | http://purl.uniprot.org/core/author | "Sullivan D.T."xsd:string |
| http://purl.uniprot.org/citations/8015438 | http://purl.uniprot.org/core/author | "Yum J."xsd:string |
| http://purl.uniprot.org/citations/8015438 | http://purl.uniprot.org/core/date | "1994"xsd:gYear |
| http://purl.uniprot.org/citations/8015438 | http://purl.uniprot.org/core/name | "Mol Biol Evol"xsd:string |
| http://purl.uniprot.org/citations/8015438 | http://purl.uniprot.org/core/pages | "443-458"xsd:string |
| http://purl.uniprot.org/citations/8015438 | http://purl.uniprot.org/core/title | "Unusual molecular evolution of an Adh pseudogene in Drosophila."xsd:string |
| http://purl.uniprot.org/citations/8015438 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/8015438 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8015438 |
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