| http://purl.uniprot.org/citations/8022784 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8022784 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8022784 | http://www.w3.org/2000/01/rdf-schema#comment | "Polyomavirus middle tumor antigen (MT) transforms a large number of cell types by binding to and modulating the activities of cellular proteins. Previous genetic analysis defined in MT an independent motif, NPTY (Asn-Pro-Thr-Tyr), required for transformation. This report demonstrates that NPTY is required for interaction between MT and SHC protein, a Src homology 2 (SH2)-containing protooncogene product implicated in activating Ras via association with GRB2 protein. SHC is phosphorylated on tyrosine and associates with GRB2 in MT-transformed cells. These effects require an intact NPTY motif in MT. SHC immunoprecipitates from MT-transformed cells possess kinase activity that phosphorylates not only SHC and MT but also the 85-kDa subunit of phosphatidylinositol 3-kinase. This result suggests that a complex exists that contains, at a minimum, MT, Src family tyrosine kinases, phosphatidylinositol 3-kinase, and SHC."xsd:string |
| http://purl.uniprot.org/citations/8022784 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.91.14.6344"xsd:string |
| http://purl.uniprot.org/citations/8022784 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.91.14.6344"xsd:string |
| http://purl.uniprot.org/citations/8022784 | http://purl.uniprot.org/core/author | "Campbell K.S."xsd:string |
| http://purl.uniprot.org/citations/8022784 | http://purl.uniprot.org/core/author | "Campbell K.S."xsd:string |
| http://purl.uniprot.org/citations/8022784 | http://purl.uniprot.org/core/author | "Pallas D.C."xsd:string |
| http://purl.uniprot.org/citations/8022784 | http://purl.uniprot.org/core/author | "Pallas D.C."xsd:string |
| http://purl.uniprot.org/citations/8022784 | http://purl.uniprot.org/core/author | "Roberts T.M."xsd:string |
| http://purl.uniprot.org/citations/8022784 | http://purl.uniprot.org/core/author | "Roberts T.M."xsd:string |
| http://purl.uniprot.org/citations/8022784 | http://purl.uniprot.org/core/author | "Ogris E."xsd:string |
| http://purl.uniprot.org/citations/8022784 | http://purl.uniprot.org/core/author | "Ogris E."xsd:string |
| http://purl.uniprot.org/citations/8022784 | http://purl.uniprot.org/core/author | "Druker B.J."xsd:string |
| http://purl.uniprot.org/citations/8022784 | http://purl.uniprot.org/core/author | "Druker B.J."xsd:string |
| http://purl.uniprot.org/citations/8022784 | http://purl.uniprot.org/core/author | "Su W."xsd:string |
| http://purl.uniprot.org/citations/8022784 | http://purl.uniprot.org/core/author | "Su W."xsd:string |
| http://purl.uniprot.org/citations/8022784 | http://purl.uniprot.org/core/author | "Auger K.R."xsd:string |
| http://purl.uniprot.org/citations/8022784 | http://purl.uniprot.org/core/author | "Auger K.R."xsd:string |
| http://purl.uniprot.org/citations/8022784 | http://purl.uniprot.org/core/author | "Burke B."xsd:string |
| http://purl.uniprot.org/citations/8022784 | http://purl.uniprot.org/core/author | "Burke B."xsd:string |
| http://purl.uniprot.org/citations/8022784 | http://purl.uniprot.org/core/author | "Schaffhausen B.S."xsd:string |
| http://purl.uniprot.org/citations/8022784 | http://purl.uniprot.org/core/author | "Schaffhausen B.S."xsd:string |
| http://purl.uniprot.org/citations/8022784 | http://purl.uniprot.org/core/date | "1994"xsd:gYear |
| http://purl.uniprot.org/citations/8022784 | http://purl.uniprot.org/core/date | "1994"xsd:gYear |