| http://purl.uniprot.org/citations/8022815 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8022815 | http://www.w3.org/2000/01/rdf-schema#comment | "We have analyzed the specificity and function of natural killer (NK) cells in mice with a homozygous deletion of the major histocompatibility complex (MHC)-encoded transporter gene associated with MHC class I-restricted antigen presentation (Tap-1). These mice express very low levels of class I molecules at the cell surface, and these molecules are either devoid of peptide or occupied only by TAP-independent peptides. NK cells in Tap-1 -/-mice, through normal in number, appeared tolerant toward autologous Tap-1 -/-Con A-activated blasts, Tap-1 -/-as well as allogeneic BALB/c bone marrow cells, and RMA-S tumor cell grafts. In contrast, they killed YAC-1 cells as efficiently as did NK cells from wild-type mice. Defective Tap-1 expression was sufficient to render nontransformed target cells sensitive to NK cell-mediated lysis. It is concluded that proper expression of TAP molecules is necessary for normal development of NK cells, as well as for rendering target cells resistant to NK cell-mediated lysis. These results support the hypothesis that class I molecules of the MHC influence the sensitivity of target cells to lysis by NK cells, as well as the development of the NK cell repertoire."xsd:string |
| http://purl.uniprot.org/citations/8022815 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.91.14.6520"xsd:string |
| http://purl.uniprot.org/citations/8022815 | http://purl.uniprot.org/core/author | "Ploegh H.L."xsd:string |
| http://purl.uniprot.org/citations/8022815 | http://purl.uniprot.org/core/author | "Ljunggren H.G."xsd:string |
| http://purl.uniprot.org/citations/8022815 | http://purl.uniprot.org/core/author | "Tonegawa S."xsd:string |
| http://purl.uniprot.org/citations/8022815 | http://purl.uniprot.org/core/author | "Van Kaer L."xsd:string |
| http://purl.uniprot.org/citations/8022815 | http://purl.uniprot.org/core/date | "1994"xsd:gYear |
| http://purl.uniprot.org/citations/8022815 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/8022815 | http://purl.uniprot.org/core/pages | "6520-6524"xsd:string |
| http://purl.uniprot.org/citations/8022815 | http://purl.uniprot.org/core/title | "Altered natural killer cell repertoire in Tap-1 mutant mice."xsd:string |
| http://purl.uniprot.org/citations/8022815 | http://purl.uniprot.org/core/volume | "91"xsd:string |
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