| http://purl.uniprot.org/citations/8024572 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8024572 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8024572 | http://www.w3.org/2000/01/rdf-schema#comment | "Initiation factor eIF-2 (a trimer of subunits alpha, beta and gamma) attaches the initiator Met-tRNA to the ribosome during the initiation of translation in eukaryotic cells. Both the alpha and beta subunits can be phosphorylated although the sites in the beta-subunit have not previously been fully identified. Here we identify the sites at which eIF-2 beta is phosphorylated in vitro by three well-characterised protein kinases, casein kinase-2 (which phosphorylates serine residues-2 and -67), protein kinase C (serine-13) and cAMP-dependent protein kinase (serine-218). This constitutes an essential prerequisite for studying the phosphorylation of eIF-2 beta in vivo. Indeed, we present evidence that at least one of these sites (serine-67) is phosphorylated in reticulocytes. The major kinase activity against eIF-2 beta in reticulocyte lysates appears in CK-2 and protein phosphatase-2A is the principal enzyme responsible for dephosphorylation of eIF-2 beta phosphorylated by this kinase."xsd:string |
| http://purl.uniprot.org/citations/8024572 | http://purl.org/dc/terms/identifier | "doi:10.1006/bbrc.1994.1843"xsd:string |
| http://purl.uniprot.org/citations/8024572 | http://purl.org/dc/terms/identifier | "doi:10.1006/bbrc.1994.1843"xsd:string |
| http://purl.uniprot.org/citations/8024572 | http://purl.uniprot.org/core/author | "Proud C.G."xsd:string |
| http://purl.uniprot.org/citations/8024572 | http://purl.uniprot.org/core/author | "Proud C.G."xsd:string |
| http://purl.uniprot.org/citations/8024572 | http://purl.uniprot.org/core/author | "Price N.T."xsd:string |
| http://purl.uniprot.org/citations/8024572 | http://purl.uniprot.org/core/author | "Price N.T."xsd:string |
| http://purl.uniprot.org/citations/8024572 | http://purl.uniprot.org/core/author | "Welsh G.I."xsd:string |
| http://purl.uniprot.org/citations/8024572 | http://purl.uniprot.org/core/author | "Welsh G.I."xsd:string |
| http://purl.uniprot.org/citations/8024572 | http://purl.uniprot.org/core/author | "Bladergroen B.A."xsd:string |
| http://purl.uniprot.org/citations/8024572 | http://purl.uniprot.org/core/author | "Bladergroen B.A."xsd:string |
| http://purl.uniprot.org/citations/8024572 | http://purl.uniprot.org/core/author | "Bloomberg G."xsd:string |
| http://purl.uniprot.org/citations/8024572 | http://purl.uniprot.org/core/author | "Bloomberg G."xsd:string |
| http://purl.uniprot.org/citations/8024572 | http://purl.uniprot.org/core/date | "1994"xsd:gYear |
| http://purl.uniprot.org/citations/8024572 | http://purl.uniprot.org/core/date | "1994"xsd:gYear |
| http://purl.uniprot.org/citations/8024572 | http://purl.uniprot.org/core/name | "Biochem. Biophys. Res. Commun."xsd:string |
| http://purl.uniprot.org/citations/8024572 | http://purl.uniprot.org/core/name | "Biochem. Biophys. Res. Commun."xsd:string |
| http://purl.uniprot.org/citations/8024572 | http://purl.uniprot.org/core/pages | "1279-1288"xsd:string |
| http://purl.uniprot.org/citations/8024572 | http://purl.uniprot.org/core/pages | "1279-1288"xsd:string |
| http://purl.uniprot.org/citations/8024572 | http://purl.uniprot.org/core/title | "Identification of novel phosphorylation sites in the beta-subunit of translation initiation factor eIF-2."xsd:string |
| http://purl.uniprot.org/citations/8024572 | http://purl.uniprot.org/core/title | "Identification of novel phosphorylation sites in the beta-subunit of translation initiation factor eIF-2."xsd:string |
| http://purl.uniprot.org/citations/8024572 | http://purl.uniprot.org/core/volume | "201"xsd:string |
| http://purl.uniprot.org/citations/8024572 | http://purl.uniprot.org/core/volume | "201"xsd:string |