| http://purl.uniprot.org/citations/8035794 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8035794 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8035794 | http://www.w3.org/2000/01/rdf-schema#comment | "Patients with humoral autoimmune diseases such as systemic lupus erythematosus and Sjögren's syndrome contain antibodies in their sera directed against certain normal cellular components such as the La/SS-B autoantigen, an RNA-binding protein believed to function as a putative processor of RNA polymerase III precursor transcripts. We have identified cDNA clones from the fruit fly Drosophila melanogaster that encode a protein displaying significant sequence homology with human La/SS-B. The fly protein (which we refer to as D-La) contains a putative ribonucleoprotein 1 (RNP1) and RNP2 RNA-binding domain. D-La also possesses a leucine zipper motif, suggesting that it may interact with itself or other proteins. Using gel retardation analysis, we show that D-La can bind RNA; in addition, we demonstrate the first reported DNA-binding activity associated with a La protein. Northern (RNA) blot analysis revealed a single 1,600-nucleotide transcript expressed throughout embryonic, larval, pupal, and adult development. Surprisingly, whole-mount in situ hybridization experiments revealed that D-La transcripts are not present in all ovarian tissues. In addition, early expression throughout the embryo is followed by a restricted pattern of mesodermal expression that is later confined to the visceral mesoderm, gonads, gut, and salivary glands. These results suggest that D-La may play a more specialized role during fly development as opposed to a rather general role inferred by its homology to La proteins from other organisms."xsd:string |
| http://purl.uniprot.org/citations/8035794 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.14.8.5123-5129.1994"xsd:string |
| http://purl.uniprot.org/citations/8035794 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.14.8.5123-5129.1994"xsd:string |
| http://purl.uniprot.org/citations/8035794 | http://purl.uniprot.org/core/author | "Li Z."xsd:string |
| http://purl.uniprot.org/citations/8035794 | http://purl.uniprot.org/core/author | "Li Z."xsd:string |
| http://purl.uniprot.org/citations/8035794 | http://purl.uniprot.org/core/author | "Bai C."xsd:string |
| http://purl.uniprot.org/citations/8035794 | http://purl.uniprot.org/core/author | "Bai C."xsd:string |
| http://purl.uniprot.org/citations/8035794 | http://purl.uniprot.org/core/author | "Tolias P.P."xsd:string |
| http://purl.uniprot.org/citations/8035794 | http://purl.uniprot.org/core/author | "Tolias P.P."xsd:string |
| http://purl.uniprot.org/citations/8035794 | http://purl.uniprot.org/core/date | "1994"xsd:gYear |
| http://purl.uniprot.org/citations/8035794 | http://purl.uniprot.org/core/date | "1994"xsd:gYear |
| http://purl.uniprot.org/citations/8035794 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/8035794 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/8035794 | http://purl.uniprot.org/core/pages | "5123-5129"xsd:string |
| http://purl.uniprot.org/citations/8035794 | http://purl.uniprot.org/core/pages | "5123-5129"xsd:string |
| http://purl.uniprot.org/citations/8035794 | http://purl.uniprot.org/core/title | "Developmental characterization of a Drosophila RNA-binding protein homologous to the human systemic lupus erythematosus-associated La/SS-B autoantigen."xsd:string |
| http://purl.uniprot.org/citations/8035794 | http://purl.uniprot.org/core/title | "Developmental characterization of a Drosophila RNA-binding protein homologous to the human systemic lupus erythematosus-associated La/SS-B autoantigen."xsd:string |
| http://purl.uniprot.org/citations/8035794 | http://purl.uniprot.org/core/volume | "14"xsd:string |
| http://purl.uniprot.org/citations/8035794 | http://purl.uniprot.org/core/volume | "14"xsd:string |
| http://purl.uniprot.org/citations/8035794 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8035794 |
| http://purl.uniprot.org/citations/8035794 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8035794 |
| http://purl.uniprot.org/citations/8035794 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/8035794 |
| http://purl.uniprot.org/citations/8035794 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/8035794 |