| http://purl.uniprot.org/citations/8041738 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8041738 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8041738 | http://www.w3.org/2000/01/rdf-schema#comment | "A cDNA corresponding to a thiol-specific antioxidant enzyme (TSA) was isolated from a rat brain cDNA library with the use of antibodies to bovine TSA. The cDNA clone encoded an open reading frame capable of encoding a 198-residue polypeptide. The rat and yeast TSA proteins show significant sequence homology to the 21-kDa component (AhpC) of Salmonella typhimurium alkyl hydroperoxide reductase, and we have found that AhpC exhibits TSA activity. AhpC and TSA define a family of > 25 different proteins present in organisms from all kingdoms. The similarity among the family members extends over the entire sequence and ranges between 23% and 98% identity. A majority of the members of the AhpC/TSA family contain two conserved cysteines. At least eight of the genes encoding AhpC/TSA-like polypeptides are found in proximity to genes encoding other oxidoreductase activities, and the expression of several of the homologs has been correlated with pathogenicity. We suggest that the AhpC/TSA family represents a widely distributed class of antioxidant enzymes. We also report that a second family of proteins, defined by the 57-kDa component (AhpF) of alkyl hydroperoxide reductase and by thioredoxin reductase, has expanded to include six additional members."xsd:string |
| http://purl.uniprot.org/citations/8041738 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.91.15.7017"xsd:string |
| http://purl.uniprot.org/citations/8041738 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.91.15.7017"xsd:string |
| http://purl.uniprot.org/citations/8041738 | http://purl.uniprot.org/core/author | "Robison K."xsd:string |
| http://purl.uniprot.org/citations/8041738 | http://purl.uniprot.org/core/author | "Robison K."xsd:string |
| http://purl.uniprot.org/citations/8041738 | http://purl.uniprot.org/core/author | "Poole L.B."xsd:string |
| http://purl.uniprot.org/citations/8041738 | http://purl.uniprot.org/core/author | "Poole L.B."xsd:string |
| http://purl.uniprot.org/citations/8041738 | http://purl.uniprot.org/core/author | "Storz G."xsd:string |
| http://purl.uniprot.org/citations/8041738 | http://purl.uniprot.org/core/author | "Storz G."xsd:string |
| http://purl.uniprot.org/citations/8041738 | http://purl.uniprot.org/core/author | "Chae H.Z."xsd:string |
| http://purl.uniprot.org/citations/8041738 | http://purl.uniprot.org/core/author | "Chae H.Z."xsd:string |
| http://purl.uniprot.org/citations/8041738 | http://purl.uniprot.org/core/author | "Church G."xsd:string |
| http://purl.uniprot.org/citations/8041738 | http://purl.uniprot.org/core/author | "Church G."xsd:string |
| http://purl.uniprot.org/citations/8041738 | http://purl.uniprot.org/core/author | "Rhee S.G."xsd:string |
| http://purl.uniprot.org/citations/8041738 | http://purl.uniprot.org/core/author | "Rhee S.G."xsd:string |
| http://purl.uniprot.org/citations/8041738 | http://purl.uniprot.org/core/date | "1994"xsd:gYear |
| http://purl.uniprot.org/citations/8041738 | http://purl.uniprot.org/core/date | "1994"xsd:gYear |
| http://purl.uniprot.org/citations/8041738 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/8041738 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/8041738 | http://purl.uniprot.org/core/pages | "7017-7021"xsd:string |
| http://purl.uniprot.org/citations/8041738 | http://purl.uniprot.org/core/pages | "7017-7021"xsd:string |
| http://purl.uniprot.org/citations/8041738 | http://purl.uniprot.org/core/title | "Cloning and sequencing of thiol-specific antioxidant from mammalian brain: alkyl hydroperoxide reductase and thiol-specific antioxidant define a large family of antioxidant enzymes."xsd:string |
| http://purl.uniprot.org/citations/8041738 | http://purl.uniprot.org/core/title | "Cloning and sequencing of thiol-specific antioxidant from mammalian brain: alkyl hydroperoxide reductase and thiol-specific antioxidant define a large family of antioxidant enzymes."xsd:string |