| http://purl.uniprot.org/citations/8069916 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8069916 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8069916 | http://www.w3.org/2000/01/rdf-schema#comment | "Mutational analysis identified a C-terminal region of 78 amino acids within the cytoplasmic domain of the human 75 kDa tumor necrosis factor receptor (TNF-R2) that is required for signal transduction. This region was subsequently shown to mediate the interaction of cytoplasmic factors with TNF-R2. Two of these factors were isolated and molecularly cloned using biochemical purification and the yeast two-hybrid system. TNF receptor-associated factor 1 (TRAF1) and TRAF2 are the first two members of a novel protein family containing a novel C-terminal homology region, the TRAF domain. In addition, TRAF2 contains an N-terminal RING finger motif. TRAF1 and TRAF2 can form homo- and heterotypic dimers. Our analysis indicates that TRAF1 and TRAF2 are associated with the cytoplasmic domain of TNF-R2 in a heterodimeric complex in which TRAF2 contacts the receptor directly. TRAF1 interacts with TNF-R2 indirectly through heterodimer formation with TRAF2."xsd:string |
| http://purl.uniprot.org/citations/8069916 | http://purl.org/dc/terms/identifier | "doi:10.1016/0092-8674(94)90532-0"xsd:string |
| http://purl.uniprot.org/citations/8069916 | http://purl.org/dc/terms/identifier | "doi:10.1016/0092-8674(94)90532-0"xsd:string |
| http://purl.uniprot.org/citations/8069916 | http://purl.uniprot.org/core/author | "Rothe M."xsd:string |
| http://purl.uniprot.org/citations/8069916 | http://purl.uniprot.org/core/author | "Rothe M."xsd:string |
| http://purl.uniprot.org/citations/8069916 | http://purl.uniprot.org/core/author | "Henzel W.J."xsd:string |
| http://purl.uniprot.org/citations/8069916 | http://purl.uniprot.org/core/author | "Henzel W.J."xsd:string |
| http://purl.uniprot.org/citations/8069916 | http://purl.uniprot.org/core/author | "Wong S.C."xsd:string |
| http://purl.uniprot.org/citations/8069916 | http://purl.uniprot.org/core/author | "Wong S.C."xsd:string |
| http://purl.uniprot.org/citations/8069916 | http://purl.uniprot.org/core/author | "Goeddel D.V."xsd:string |
| http://purl.uniprot.org/citations/8069916 | http://purl.uniprot.org/core/author | "Goeddel D.V."xsd:string |
| http://purl.uniprot.org/citations/8069916 | http://purl.uniprot.org/core/date | "1994"xsd:gYear |
| http://purl.uniprot.org/citations/8069916 | http://purl.uniprot.org/core/date | "1994"xsd:gYear |
| http://purl.uniprot.org/citations/8069916 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/8069916 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/8069916 | http://purl.uniprot.org/core/pages | "681-692"xsd:string |
| http://purl.uniprot.org/citations/8069916 | http://purl.uniprot.org/core/pages | "681-692"xsd:string |
| http://purl.uniprot.org/citations/8069916 | http://purl.uniprot.org/core/title | "A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor."xsd:string |
| http://purl.uniprot.org/citations/8069916 | http://purl.uniprot.org/core/title | "A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor."xsd:string |
| http://purl.uniprot.org/citations/8069916 | http://purl.uniprot.org/core/volume | "78"xsd:string |
| http://purl.uniprot.org/citations/8069916 | http://purl.uniprot.org/core/volume | "78"xsd:string |
| http://purl.uniprot.org/citations/8069916 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8069916 |
| http://purl.uniprot.org/citations/8069916 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8069916 |