| http://purl.uniprot.org/citations/8076514 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8076514 | http://www.w3.org/2000/01/rdf-schema#comment | "In mice, only the paternal allele of the Igf2 gene, encoding insulin-like growth factor II (IGF-II) is expressed due to parental imprinting. Interestingly, the Igf2r gene, which encodes one of the two known receptors (IGF2R) to which IGF-II binds with high affinity is also subject to imprinting, but in a reciprocal fashion. This observation raises the possibility that imprinting of these loci serves to regulate the ratios of the gene products, since IGF2R provides a mechanism for IGF-II turnover. To test this hypothesis, we crossed mice mutant for Igf-2 with animals carrying the Thp chromosomal deletion, which encompasses the Igf2r locus. Inheritance of the Thp chromosome through the maternal germline results in a dominant lethal maternal effect (Tme). However, as we show here, Thp/+ embryos that inherit the Thp maternally are variably rescued to birth if they also lack IGF-II. Based on these data, the Tme phenotype can be viewed as a dominant effect resulting from an overabundance of IGF-II."xsd:string |
| http://purl.uniprot.org/citations/8076514 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.118.3.731"xsd:string |
| http://purl.uniprot.org/citations/8076514 | http://purl.uniprot.org/core/author | "Robertson E.J."xsd:string |
| http://purl.uniprot.org/citations/8076514 | http://purl.uniprot.org/core/author | "Louvi A."xsd:string |
| http://purl.uniprot.org/citations/8076514 | http://purl.uniprot.org/core/author | "Efstratiadis A."xsd:string |
| http://purl.uniprot.org/citations/8076514 | http://purl.uniprot.org/core/author | "Filson A.J."xsd:string |
| http://purl.uniprot.org/citations/8076514 | http://purl.uniprot.org/core/date | "1993"xsd:gYear |
| http://purl.uniprot.org/citations/8076514 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/8076514 | http://purl.uniprot.org/core/pages | "731-736"xsd:string |
| http://purl.uniprot.org/citations/8076514 | http://purl.uniprot.org/core/title | "Rescue of the T-associated maternal effect in mice carrying null mutations in Igf-2 and Igf2r, two reciprocally imprinted genes."xsd:string |
| http://purl.uniprot.org/citations/8076514 | http://purl.uniprot.org/core/volume | "118"xsd:string |
| http://purl.uniprot.org/citations/8076514 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8076514 |
| http://purl.uniprot.org/citations/8076514 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/8076514 |
| http://purl.uniprot.org/uniprot/#_D3Z1X4-mappedCitation-8076514 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8076514 |
| http://purl.uniprot.org/uniprot/#_B9EKB8-mappedCitation-8076514 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8076514 |
| http://purl.uniprot.org/uniprot/#_B0LAD8-mappedCitation-8076514 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8076514 |
| http://purl.uniprot.org/uniprot/#_B7ZWC4-mappedCitation-8076514 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8076514 |
| http://purl.uniprot.org/uniprot/#_D3Z4N4-mappedCitation-8076514 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8076514 |
| http://purl.uniprot.org/uniprot/#_J3QJZ9-mappedCitation-8076514 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8076514 |
| http://purl.uniprot.org/uniprot/#_H3BKU2-mappedCitation-8076514 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8076514 |
| http://purl.uniprot.org/uniprot/#_P20293-mappedCitation-8076514 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8076514 |
| http://purl.uniprot.org/uniprot/#_P09535-mappedCitation-8076514 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8076514 |
| http://purl.uniprot.org/uniprot/#_Q07113-mappedCitation-8076514 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8076514 |
| http://purl.uniprot.org/uniprot/#_Q78ZW9-mappedCitation-8076514 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8076514 |