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http://purl.uniprot.org/citations/8076653http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/8076653http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/8076653http://www.w3.org/2000/01/rdf-schema#comment"UDP-glucose:dolichyl-phosphate glucosyltransferase is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate. The structural gene encoding this transferase from Saccharomyces cerevisiae was isolated by complementation of an alg5-1 mutation. DNA sequencing of ALG5 revealed an open-reading frame of 1002 bases encoding a transmembrane protein of molecular mass 38.3 kDa. Overexpression of Alg5p in both yeast and Escherichia coli results in an increase of UDP-glucose:dolichyl-phosphate glucosyltransferase activity, whereas a deletion of the yeast gene leads to a loss of this activity and a concomitant underglycosylation of carboxypeptidase Y. The ALG5 protein has sequence similarity to the GDP-mannose:dolichyl-phosphate mannosyltransferase (Dpm1p) from S. cerevisiae. Topological studies indicate that UDP-glucose:dolichyl-phosphate glucosyltransferase is a transmembrane protein that spans the membrane several times."xsd:string
http://purl.uniprot.org/citations/8076653http://purl.org/dc/terms/identifier"doi:10.1111/j.1432-1033.1994.tb19996.x"xsd:string
http://purl.uniprot.org/citations/8076653http://purl.org/dc/terms/identifier"doi:10.1111/j.1432-1033.1994.tb19996.x"xsd:string
http://purl.uniprot.org/citations/8076653http://purl.uniprot.org/core/author"Aebi M."xsd:string
http://purl.uniprot.org/citations/8076653http://purl.uniprot.org/core/author"Aebi M."xsd:string
http://purl.uniprot.org/citations/8076653http://purl.uniprot.org/core/author"Lehle L."xsd:string
http://purl.uniprot.org/citations/8076653http://purl.uniprot.org/core/author"Lehle L."xsd:string
http://purl.uniprot.org/citations/8076653http://purl.uniprot.org/core/author"Te Heesen S."xsd:string
http://purl.uniprot.org/citations/8076653http://purl.uniprot.org/core/author"Te Heesen S."xsd:string
http://purl.uniprot.org/citations/8076653http://purl.uniprot.org/core/author"Weissmann A."xsd:string
http://purl.uniprot.org/citations/8076653http://purl.uniprot.org/core/author"Weissmann A."xsd:string
http://purl.uniprot.org/citations/8076653http://purl.uniprot.org/core/date"1994"xsd:gYear
http://purl.uniprot.org/citations/8076653http://purl.uniprot.org/core/date"1994"xsd:gYear
http://purl.uniprot.org/citations/8076653http://purl.uniprot.org/core/name"Eur. J. Biochem."xsd:string
http://purl.uniprot.org/citations/8076653http://purl.uniprot.org/core/name"Eur. J. Biochem."xsd:string
http://purl.uniprot.org/citations/8076653http://purl.uniprot.org/core/pages"71-79"xsd:string
http://purl.uniprot.org/citations/8076653http://purl.uniprot.org/core/pages"71-79"xsd:string
http://purl.uniprot.org/citations/8076653http://purl.uniprot.org/core/title"Isolation of the ALG5 locus encoding the UDP-glucose:dolichyl-phosphate glucosyltransferase from Saccharomyces cerevisiae."xsd:string
http://purl.uniprot.org/citations/8076653http://purl.uniprot.org/core/title"Isolation of the ALG5 locus encoding the UDP-glucose:dolichyl-phosphate glucosyltransferase from Saccharomyces cerevisiae."xsd:string
http://purl.uniprot.org/citations/8076653http://purl.uniprot.org/core/volume"224"xsd:string
http://purl.uniprot.org/citations/8076653http://purl.uniprot.org/core/volume"224"xsd:string
http://purl.uniprot.org/citations/8076653http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/8076653
http://purl.uniprot.org/citations/8076653http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/8076653