| http://purl.uniprot.org/citations/8089148 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8089148 | http://www.w3.org/2000/01/rdf-schema#comment | "Hypoxia-inducible factor 1 (HIF-1) activates erythropoietin gene transcription in Hep3B cells subjected to hypoxia. HIF-1 activity is also induced by hypoxia in non-erythropoietin-producing cells, suggesting a more general regulatory role. We now report that RNAs encoding the glycolytic enzymes aldolase A (ALDA), phosphoglycerate kinase 1 (PGK1), and pyruvate kinase M were induced by exposure of Hep3B or HeLa cells to inducers of HIF-1 (1% O2, cobalt chloride, or desferrioxamine), whereas cycloheximide blocked induction of glycolytic RNAs and HIF-1 activity. Oligonucleotides from the ALDA, PGK1, enolase 1, lactate dehydrogenase A, and phosphofructokinase L (PFKL) genes, containing sequences similar to the HIF-1 binding site in the erythropoietin enhancer, specifically bound HIF-1 present in crude nuclear extracts or affinity-purified preparations. Sequences from the ALDA, PFKL, and PGK1 genes containing HIF-1 binding sites mediated hypoxia-inducible transcription in transient expression assays. These results support the role of HIF-1 as a mediator of adaptive responses to hypoxia that underlie cellular and systemic oxygen homeostasis."xsd:string |
| http://purl.uniprot.org/citations/8089148 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0021-9258(17)31580-6"xsd:string |
| http://purl.uniprot.org/citations/8089148 | http://purl.uniprot.org/core/author | "Wang G.L."xsd:string |
| http://purl.uniprot.org/citations/8089148 | http://purl.uniprot.org/core/author | "Semenza G.L."xsd:string |
| http://purl.uniprot.org/citations/8089148 | http://purl.uniprot.org/core/author | "Fang H.M."xsd:string |
| http://purl.uniprot.org/citations/8089148 | http://purl.uniprot.org/core/author | "Roth P.H."xsd:string |
| http://purl.uniprot.org/citations/8089148 | http://purl.uniprot.org/core/date | "1994"xsd:gYear |
| http://purl.uniprot.org/citations/8089148 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/8089148 | http://purl.uniprot.org/core/pages | "23757-23763"xsd:string |
| http://purl.uniprot.org/citations/8089148 | http://purl.uniprot.org/core/title | "Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1."xsd:string |
| http://purl.uniprot.org/citations/8089148 | http://purl.uniprot.org/core/volume | "269"xsd:string |
| http://purl.uniprot.org/citations/8089148 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8089148 |
| http://purl.uniprot.org/citations/8089148 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/8089148 |
| http://purl.uniprot.org/uniprot/P27540#attribution-09E26E619749470896DF19AE23A9D7D2 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/8089148 |
| http://purl.uniprot.org/uniprot/P27540#attribution-F54CC27C88E1E125307010124D76858F | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/8089148 |
| http://purl.uniprot.org/uniprot/Q16665#attribution-09E26E619749470896DF19AE23A9D7D2 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/8089148 |
| http://purl.uniprot.org/uniprot/Q16665#attribution-F54CC27C88E1E125307010124D76858F | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/8089148 |