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| http://purl.uniprot.org/citations/8103927 | http://www.w3.org/2000/01/rdf-schema#comment | "During Caenorhabditis elegans vulval induction, multipotent precursors respond to an inductive signal by generating vulval cells as opposed to non-specialized epidermal cells. Both classical and 'reverse' genetic approaches have revealed that a cascade of nematode homologues of mammalian proto-oncogenes is necessary for induction of the vulva. The inductive signal is a growth factor encoded by the lin-3 gene and its candidate receptor is a tyrosine kinase encoded by the let-23 gene. let-23 acts via a Ras protein encoded by the let-60 gene. A nematode homologue of mammalian raf family protein serine/threonine kinases has been cloned and found to be encoded by the lin-45 gene. Dominant negative lin-45 raf mutants prevent vulval induction. A recessive lin-45 raf mutation prevents the excessive vulval differentiation caused by activated ras, indicating that raf might act downstream of ras during vulval induction."xsd:string |
| http://purl.uniprot.org/citations/8103927 | http://purl.org/dc/terms/identifier | "doi:10.1098/rstb.1993.0066"xsd:string |
| http://purl.uniprot.org/citations/8103927 | http://purl.uniprot.org/core/author | "Han M."xsd:string |
| http://purl.uniprot.org/citations/8103927 | http://purl.uniprot.org/core/author | "Sternberg P.W."xsd:string |
| http://purl.uniprot.org/citations/8103927 | http://purl.uniprot.org/core/author | "Golden A."xsd:string |
| http://purl.uniprot.org/citations/8103927 | http://purl.uniprot.org/core/date | "1993"xsd:gYear |
| http://purl.uniprot.org/citations/8103927 | http://purl.uniprot.org/core/name | "Philos Trans R Soc Lond B Biol Sci"xsd:string |
| http://purl.uniprot.org/citations/8103927 | http://purl.uniprot.org/core/pages | "259-265"xsd:string |
| http://purl.uniprot.org/citations/8103927 | http://purl.uniprot.org/core/title | "Role of a raf proto-oncogene during Caenorhabditis elegans vulval development."xsd:string |
| http://purl.uniprot.org/citations/8103927 | http://purl.uniprot.org/core/volume | "340"xsd:string |
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