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http://purl.uniprot.org/citations/8107774http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/8107774http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/8107774http://www.w3.org/2000/01/rdf-schema#comment"A new brain serine/threonine protein kinase may be a target for the p21ras-related proteins Cdc42 and Rac1. The kinase sequence is related to that of the yeast protein STE20, implicated in pheromone-response pathways. The kinase complexes specifically with activated (GTP-bound) p21, inhibiting p21 GTPase activity and leading to kinase autophosphorylation and activation. Autophosphorylated kinase has a decreased affinity for Cdc42/Rac, freeing the p21 for further stimulatory activities or downregulation by GTPase-activating proteins. This bimolecular interaction provides a model for studying p21 regulation of mammalian phosphorylation signalling pathways."xsd:string
http://purl.uniprot.org/citations/8107774http://purl.org/dc/terms/identifier"doi:10.1038/367040a0"xsd:string
http://purl.uniprot.org/citations/8107774http://purl.org/dc/terms/identifier"doi:10.1038/367040a0"xsd:string
http://purl.uniprot.org/citations/8107774http://purl.uniprot.org/core/author"Lim L."xsd:string
http://purl.uniprot.org/citations/8107774http://purl.uniprot.org/core/author"Lim L."xsd:string
http://purl.uniprot.org/citations/8107774http://purl.uniprot.org/core/author"Manser E."xsd:string
http://purl.uniprot.org/citations/8107774http://purl.uniprot.org/core/author"Manser E."xsd:string
http://purl.uniprot.org/citations/8107774http://purl.uniprot.org/core/author"Leung T."xsd:string
http://purl.uniprot.org/citations/8107774http://purl.uniprot.org/core/author"Leung T."xsd:string
http://purl.uniprot.org/citations/8107774http://purl.uniprot.org/core/author"Salihuddin H."xsd:string
http://purl.uniprot.org/citations/8107774http://purl.uniprot.org/core/author"Salihuddin H."xsd:string
http://purl.uniprot.org/citations/8107774http://purl.uniprot.org/core/author"Zhao Z.-S."xsd:string
http://purl.uniprot.org/citations/8107774http://purl.uniprot.org/core/author"Zhao Z.-S."xsd:string
http://purl.uniprot.org/citations/8107774http://purl.uniprot.org/core/date"1994"xsd:gYear
http://purl.uniprot.org/citations/8107774http://purl.uniprot.org/core/date"1994"xsd:gYear
http://purl.uniprot.org/citations/8107774http://purl.uniprot.org/core/name"Nature"xsd:string
http://purl.uniprot.org/citations/8107774http://purl.uniprot.org/core/name"Nature"xsd:string
http://purl.uniprot.org/citations/8107774http://purl.uniprot.org/core/pages"40-46"xsd:string
http://purl.uniprot.org/citations/8107774http://purl.uniprot.org/core/pages"40-46"xsd:string
http://purl.uniprot.org/citations/8107774http://purl.uniprot.org/core/title"A brain serine/threonine protein kinase activated by Cdc42 and Rac1."xsd:string
http://purl.uniprot.org/citations/8107774http://purl.uniprot.org/core/title"A brain serine/threonine protein kinase activated by Cdc42 and Rac1."xsd:string
http://purl.uniprot.org/citations/8107774http://purl.uniprot.org/core/volume"367"xsd:string
http://purl.uniprot.org/citations/8107774http://purl.uniprot.org/core/volume"367"xsd:string