| http://purl.uniprot.org/citations/8107781 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8107781 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8107781 | http://www.w3.org/2000/01/rdf-schema#comment | "Superantigens stimulate T cells bearing particular T-cell receptor V beta sequences, so they are extremely potent polyclonal T-cell mitogens. T-cell activation is preceded by binding of superantigens to class II major histocompatibility complex (MHC) molecules. To further the structural characterization of these interactions, the crystal structure of a toxin associated with toxic-shock syndrome, TSST-1, which is a microbial superantigen, has been determined at 2.5 A resolution. The N- and C-terminal domains of the structure both contain regions involved in MHC class II association; the C-terminal domain is also implicated in binding the T-cell receptor. Despite low sequence conservation, the TSST-1 topology is similar to the structure reported for the superantigen staphylococcal enterotoxin B4. But TSST-1 lacks several of the structural features highlighted as central to superantigen activity in the staphylococcal enterotoxin B and we therefore reappraise the structural basis of superantigen action."xsd:string |
| http://purl.uniprot.org/citations/8107781 | http://purl.org/dc/terms/identifier | "doi:10.1038/367094a0"xsd:string |
| http://purl.uniprot.org/citations/8107781 | http://purl.org/dc/terms/identifier | "doi:10.1038/367094a0"xsd:string |
| http://purl.uniprot.org/citations/8107781 | http://purl.uniprot.org/core/author | "Acharya K.R."xsd:string |
| http://purl.uniprot.org/citations/8107781 | http://purl.uniprot.org/core/author | "Acharya K.R."xsd:string |
| http://purl.uniprot.org/citations/8107781 | http://purl.uniprot.org/core/author | "Stuart D.I."xsd:string |
| http://purl.uniprot.org/citations/8107781 | http://purl.uniprot.org/core/author | "Stuart D.I."xsd:string |
| http://purl.uniprot.org/citations/8107781 | http://purl.uniprot.org/core/author | "Harlos K."xsd:string |
| http://purl.uniprot.org/citations/8107781 | http://purl.uniprot.org/core/author | "Harlos K."xsd:string |
| http://purl.uniprot.org/citations/8107781 | http://purl.uniprot.org/core/author | "Jones E.Y."xsd:string |
| http://purl.uniprot.org/citations/8107781 | http://purl.uniprot.org/core/author | "Jones E.Y."xsd:string |
| http://purl.uniprot.org/citations/8107781 | http://purl.uniprot.org/core/author | "Brehm R.D."xsd:string |
| http://purl.uniprot.org/citations/8107781 | http://purl.uniprot.org/core/author | "Brehm R.D."xsd:string |
| http://purl.uniprot.org/citations/8107781 | http://purl.uniprot.org/core/author | "Passalacqua E.F."xsd:string |
| http://purl.uniprot.org/citations/8107781 | http://purl.uniprot.org/core/author | "Passalacqua E.F."xsd:string |
| http://purl.uniprot.org/citations/8107781 | http://purl.uniprot.org/core/author | "Tranter H.S."xsd:string |
| http://purl.uniprot.org/citations/8107781 | http://purl.uniprot.org/core/author | "Tranter H.S."xsd:string |
| http://purl.uniprot.org/citations/8107781 | http://purl.uniprot.org/core/date | "1994"xsd:gYear |
| http://purl.uniprot.org/citations/8107781 | http://purl.uniprot.org/core/date | "1994"xsd:gYear |
| http://purl.uniprot.org/citations/8107781 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/8107781 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/8107781 | http://purl.uniprot.org/core/pages | "94-97"xsd:string |
| http://purl.uniprot.org/citations/8107781 | http://purl.uniprot.org/core/pages | "94-97"xsd:string |