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http://purl.uniprot.org/citations/8107851http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/8107851http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/8107851http://www.w3.org/2000/01/rdf-schema#comment"Protein translocation into the mammalian endoplasmic reticulum requires the Sec61p complex, which consists of three membrane proteins. The alpha-subunit, the homologue of Sec61p of yeast, shows some similarity to SecYp, a key component of the protein export apparatus of bacteria. In Escherichia coli, SecYp is also associated with two other proteins (SecEp and band-1 protein). We have now determined the sequences of the beta- and gamma-subunits of the mammalian Sec61p complex. Sec61-gamma is homologous to SSS1p, a suppressor of sec61 mutants in Saccharomyces cerevisiae, and can functionally replace it in yeast cells. Moreover, Sec61-gamma and SSS1p are structurally related to SecEp of E. coli and to putative homologues in various other bacteria. At least two subunits of the Sec61/SecYp complex therefore seem to be key components of the protein translocation apparatus in all classes of organisms."xsd:string
http://purl.uniprot.org/citations/8107851http://purl.org/dc/terms/identifier"doi:10.1038/367654a0"xsd:string
http://purl.uniprot.org/citations/8107851http://purl.org/dc/terms/identifier"doi:10.1038/367654a0"xsd:string
http://purl.uniprot.org/citations/8107851http://purl.uniprot.org/core/author"Goerlich D."xsd:string
http://purl.uniprot.org/citations/8107851http://purl.uniprot.org/core/author"Goerlich D."xsd:string
http://purl.uniprot.org/citations/8107851http://purl.uniprot.org/core/author"Rapoport T.A."xsd:string
http://purl.uniprot.org/citations/8107851http://purl.uniprot.org/core/author"Rapoport T.A."xsd:string
http://purl.uniprot.org/citations/8107851http://purl.uniprot.org/core/author"Jentsch S."xsd:string
http://purl.uniprot.org/citations/8107851http://purl.uniprot.org/core/author"Jentsch S."xsd:string
http://purl.uniprot.org/citations/8107851http://purl.uniprot.org/core/author"Hartmann E."xsd:string
http://purl.uniprot.org/citations/8107851http://purl.uniprot.org/core/author"Hartmann E."xsd:string
http://purl.uniprot.org/citations/8107851http://purl.uniprot.org/core/author"Sommer T."xsd:string
http://purl.uniprot.org/citations/8107851http://purl.uniprot.org/core/author"Sommer T."xsd:string
http://purl.uniprot.org/citations/8107851http://purl.uniprot.org/core/author"Prehn S."xsd:string
http://purl.uniprot.org/citations/8107851http://purl.uniprot.org/core/author"Prehn S."xsd:string
http://purl.uniprot.org/citations/8107851http://purl.uniprot.org/core/date"1994"xsd:gYear
http://purl.uniprot.org/citations/8107851http://purl.uniprot.org/core/date"1994"xsd:gYear
http://purl.uniprot.org/citations/8107851http://purl.uniprot.org/core/name"Nature"xsd:string
http://purl.uniprot.org/citations/8107851http://purl.uniprot.org/core/name"Nature"xsd:string
http://purl.uniprot.org/citations/8107851http://purl.uniprot.org/core/pages"654-657"xsd:string
http://purl.uniprot.org/citations/8107851http://purl.uniprot.org/core/pages"654-657"xsd:string
http://purl.uniprot.org/citations/8107851http://purl.uniprot.org/core/title"Evolutionary conservation of components of the protein translocation complex."xsd:string
http://purl.uniprot.org/citations/8107851http://purl.uniprot.org/core/title"Evolutionary conservation of components of the protein translocation complex."xsd:string