| http://purl.uniprot.org/citations/8119964 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8119964 | http://www.w3.org/2000/01/rdf-schema#comment | "The Wilms' tumor suppressor gene WT1 encodes a zinc-finger DNA-binding protein that functions as a transcriptional repressor. WT1 is expressed in a dramatic spatial and temporal pattern during kidney development and is thought to be critical during mesenchymal-epithelial conversion. The WT1 protein bound multiple sites in the WT1 promoter and functioned as a powerful transcriptional repressor of its gene in vivo (> 50-fold). The WT1 protein carrying an NH2-terminal 17-amino acid insertion and a 3-amino acid insertion (KTS) between zinc fingers 3 and 4, arising from the most abundant of four alternatively spliced transcripts, was the most powerful repressor. Of importance, a subset of WT1-binding sites differs from the Egr-1 consensus sequence, which has been shown to bind one splice variant of the WT1 protein (WT1(-KTS)). We characterized two of these sites and show that they bind both -KTS and +KTS forms of the WT1 zinc-finger protein and can confer repression on a heterologous promoter construct. Our data demonstrate that WT1, in addition to its known effects on insulin-like growth factor II, platelet-derived growth factor A, and Pax-2 transcription, is a powerful repressor of its own gene. These observations emphasize its critical role as a transcriptional regulatory protein during normal kidney development."xsd:string |
| http://purl.uniprot.org/citations/8119964 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0021-9258(17)37588-9"xsd:string |
| http://purl.uniprot.org/citations/8119964 | http://purl.uniprot.org/core/author | "Drummond I.A."xsd:string |
| http://purl.uniprot.org/citations/8119964 | http://purl.uniprot.org/core/author | "Sukhatme V.P."xsd:string |
| http://purl.uniprot.org/citations/8119964 | http://purl.uniprot.org/core/author | "Madden S.L."xsd:string |
| http://purl.uniprot.org/citations/8119964 | http://purl.uniprot.org/core/author | "Rauscher F.J."xsd:string |
| http://purl.uniprot.org/citations/8119964 | http://purl.uniprot.org/core/author | "Rupprecht H.D."xsd:string |
| http://purl.uniprot.org/citations/8119964 | http://purl.uniprot.org/core/date | "1994"xsd:gYear |
| http://purl.uniprot.org/citations/8119964 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/8119964 | http://purl.uniprot.org/core/pages | "6198-6206"xsd:string |
| http://purl.uniprot.org/citations/8119964 | http://purl.uniprot.org/core/title | "The Wilms' tumor suppressor gene WT1 is negatively autoregulated."xsd:string |
| http://purl.uniprot.org/citations/8119964 | http://purl.uniprot.org/core/volume | "269"xsd:string |
| http://purl.uniprot.org/citations/8119964 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8119964 |
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