| http://purl.uniprot.org/citations/8124727 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8124727 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8124727 | http://www.w3.org/2000/01/rdf-schema#comment | "We have previously described a type of selective T cell deficiency (STD) characterized by persistent infections reminiscent of severe combined immunodeficiency. We show here that STD patients carry a mutation of zap-70, resulting in loss of the activity of this kinase. The thymi of zap-70-/-patients show the presence of CD4+CD8+ cells in the cortex; however, only CD4, not CD8, single-positive cells are present in the medulla. Peripheral CD4+ T cells from the zap-70-/-patients exhibit markedly reduced tyrosine phosphorylation, fail to produce interleukin-2, and do not proliferate in response to T cell receptor stimulation by mitogens or antigens. Thus, Zap-70 kinase appears to be indispensable for the development of CD8 single-positive T cells as well as for signal transduction and function of single-positive CD4 T cells."xsd:string |
| http://purl.uniprot.org/citations/8124727 | http://purl.org/dc/terms/identifier | "doi:10.1016/0092-8674(94)90368-9"xsd:string |
| http://purl.uniprot.org/citations/8124727 | http://purl.org/dc/terms/identifier | "doi:10.1016/0092-8674(94)90368-9"xsd:string |
| http://purl.uniprot.org/citations/8124727 | http://purl.uniprot.org/core/author | "Cohen A."xsd:string |
| http://purl.uniprot.org/citations/8124727 | http://purl.uniprot.org/core/author | "Cohen A."xsd:string |
| http://purl.uniprot.org/citations/8124727 | http://purl.uniprot.org/core/author | "Roifman C.M."xsd:string |
| http://purl.uniprot.org/citations/8124727 | http://purl.uniprot.org/core/author | "Roifman C.M."xsd:string |
| http://purl.uniprot.org/citations/8124727 | http://purl.uniprot.org/core/author | "Arpaia E."xsd:string |
| http://purl.uniprot.org/citations/8124727 | http://purl.uniprot.org/core/author | "Arpaia E."xsd:string |
| http://purl.uniprot.org/citations/8124727 | http://purl.uniprot.org/core/author | "Shahar M."xsd:string |
| http://purl.uniprot.org/citations/8124727 | http://purl.uniprot.org/core/author | "Shahar M."xsd:string |
| http://purl.uniprot.org/citations/8124727 | http://purl.uniprot.org/core/author | "Dadi H."xsd:string |
| http://purl.uniprot.org/citations/8124727 | http://purl.uniprot.org/core/author | "Dadi H."xsd:string |
| http://purl.uniprot.org/citations/8124727 | http://purl.uniprot.org/core/date | "1994"xsd:gYear |
| http://purl.uniprot.org/citations/8124727 | http://purl.uniprot.org/core/date | "1994"xsd:gYear |
| http://purl.uniprot.org/citations/8124727 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/8124727 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/8124727 | http://purl.uniprot.org/core/pages | "947-958"xsd:string |
| http://purl.uniprot.org/citations/8124727 | http://purl.uniprot.org/core/pages | "947-958"xsd:string |
| http://purl.uniprot.org/citations/8124727 | http://purl.uniprot.org/core/title | "Defective T cell receptor signaling and CD8+ thymic selection in humans lacking zap-70 kinase."xsd:string |
| http://purl.uniprot.org/citations/8124727 | http://purl.uniprot.org/core/title | "Defective T cell receptor signaling and CD8+ thymic selection in humans lacking zap-70 kinase."xsd:string |
| http://purl.uniprot.org/citations/8124727 | http://purl.uniprot.org/core/volume | "76"xsd:string |
| http://purl.uniprot.org/citations/8124727 | http://purl.uniprot.org/core/volume | "76"xsd:string |