| http://purl.uniprot.org/citations/8133891 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8133891 | http://www.w3.org/2000/01/rdf-schema#comment | "Expression of antigen receptors is vital for the development of B and T lymphocytes. In mice with the scid mutation, which are unable to make productive rearrangements of their immunoglobulin and T-cell receptor (TCR) genes, lymphopoiesis aborts at an early stage. The death of the immature lymphocytes by apoptosis is postulated to result from a failure to receive a survival signal induced by receptor engagement. Consistent with this hypothesis, introduction of immunoglobulin or TCR transgenes into scid mice promoted an increase in B- or T-lymphoid cells, respectively. As the protein encoded by the bcl-2 gene can inhibit cell death, we tested whether lymphopoiesis could be rescued in scid mice by crossing in a bcl-2 transgene. Strikingly, the bcl-2/scid mice accumulated almost normal numbers of B-lymphoid cells which lacked surface immunoglobulin but expressed markers of maturity. T-cell development remained blocked. Introducing a TCR transgene enabled bcl-2/scid mice to develop normal numbers of CD4+8+ thymocytes even in the absence of immunological selection, suggesting that T cells become competent to respond to bcl-2 protein only after the TCR complex is displayed at the cell surface."xsd:string |
| http://purl.uniprot.org/citations/8133891 | http://purl.org/dc/terms/identifier | "doi:10.1038/368457a0"xsd:string |
| http://purl.uniprot.org/citations/8133891 | http://purl.uniprot.org/core/author | "Corcoran L.M."xsd:string |
| http://purl.uniprot.org/citations/8133891 | http://purl.uniprot.org/core/author | "Strasser A."xsd:string |
| http://purl.uniprot.org/citations/8133891 | http://purl.uniprot.org/core/author | "Cory S."xsd:string |
| http://purl.uniprot.org/citations/8133891 | http://purl.uniprot.org/core/author | "Harris A.W."xsd:string |
| http://purl.uniprot.org/citations/8133891 | http://purl.uniprot.org/core/date | "1994"xsd:gYear |
| http://purl.uniprot.org/citations/8133891 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/8133891 | http://purl.uniprot.org/core/pages | "457-460"xsd:string |
| http://purl.uniprot.org/citations/8133891 | http://purl.uniprot.org/core/title | "Bcl-2 expression promotes B- but not T-lymphoid development in scid mice."xsd:string |
| http://purl.uniprot.org/citations/8133891 | http://purl.uniprot.org/core/volume | "368"xsd:string |
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