| http://purl.uniprot.org/citations/8143864 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8143864 | http://www.w3.org/2000/01/rdf-schema#comment | "Muscular dysgenesis (mdg) is a spontaneous mutation affecting the alpha 1 subunit of the skeletal L-type Ca2+ channel. mdg/mdg mice suffer from a skeletal muscle disease characterised by low levels of the slow Ca2+ current, lack of contractile activity, and immature organisation of skeletal muscle. Microinjections of a cDNA encoding alpha 1 into mutant myotubes restore excitation-contraction coupling. We checked here that dysgenic myotubes transfected with expression vectors, including a full-length alpha 1 cDNA, also recover normal ultrastructural features. Transfection of alpha 1 cDNA partially deleted on the 5' end leads to the recovery of a good structural organisation without any improvement in the mutant physiological phenotype. These results suggest that: (i) the proper expression of alpha 1 is required for the full muscle differentiation of muscular dysgenesis myotubes, and (ii) portions of the alpha 1 molecule may be involved in the structural organisation of a muscle fiber, independent of its known functional properties."xsd:string |
| http://purl.uniprot.org/citations/8143864 | http://purl.org/dc/terms/identifier | "doi:10.1016/0014-5793(94)80486-9"xsd:string |
| http://purl.uniprot.org/citations/8143864 | http://purl.uniprot.org/core/author | "Song M."xsd:string |
| http://purl.uniprot.org/citations/8143864 | http://purl.uniprot.org/core/author | "Garcia L."xsd:string |
| http://purl.uniprot.org/citations/8143864 | http://purl.uniprot.org/core/author | "Rieger F."xsd:string |
| http://purl.uniprot.org/citations/8143864 | http://purl.uniprot.org/core/author | "Pincon-Raymond M."xsd:string |
| http://purl.uniprot.org/citations/8143864 | http://purl.uniprot.org/core/author | "Seigneurin-Venin S."xsd:string |
| http://purl.uniprot.org/citations/8143864 | http://purl.uniprot.org/core/date | "1994"xsd:gYear |
| http://purl.uniprot.org/citations/8143864 | http://purl.uniprot.org/core/name | "FEBS Lett"xsd:string |
| http://purl.uniprot.org/citations/8143864 | http://purl.uniprot.org/core/pages | "129-134"xsd:string |
| http://purl.uniprot.org/citations/8143864 | http://purl.uniprot.org/core/title | "Restoration of normal ultrastructure after expression of the alpha 1 subunit of the L-type Ca2+ channel in dysgenic myotubes."xsd:string |
| http://purl.uniprot.org/citations/8143864 | http://purl.uniprot.org/core/volume | "342"xsd:string |
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