| http://purl.uniprot.org/citations/8144928 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8144928 | http://www.w3.org/2000/01/rdf-schema#comment | "The murine B cell IgE receptor (Fc epsilon RII, CD23) has been implicated in various functions including IgE regulation, Ag presentation, and B cell differentiation/activation. We have undertaken a series of studies to identify promoter sequences that are important for the constitutive and IL-4-induced expression of the murine Fc epsilon RII in M12.4.5 B lymphoma cells. By use of RNase protection analysis it was established that murine splenic B cells and M12.4.5 cells predominantly express the Fc epsilon RIIa form and that this receptor subtype accounts for the vast majority of IL-4-induced Fc epsilon RII mRNA in B cells. A 101-bp segment of the murine Fc epsilon RII proximal promoter coupled to a heterologous SV40 promoter was found to impart IL-4 inducibility in reporter assays. Removal of either 10 bp from the 5' end or 17 bp from the 3' end of this 101-bp fragment substantially reduced the IL-4 response. Both of these terminal deletions removed sequences that share homology with established IL-4 response elements of MHC class II and Ig (gamma 1 and epsilon) heavy chain genes. In addition, near the center of this 101-bp fragment lies a sequence that is highly homologous with NF-kappa B/LPS response elements previously identified upstream of the A alpha gene. DNA fragments containing this sequence together with one of the putative IL-4 response elements were able to impart a small LPS/IL-4 response in M12.4.5 cells. These results suggest that IL-4 and LPS induction of murine B cell Fc epsilon RII expression is mediated by a complex of transcription factors."xsd:string |
| http://purl.uniprot.org/citations/8144928 | http://purl.uniprot.org/core/author | "Richards M.L."xsd:string |
| http://purl.uniprot.org/citations/8144928 | http://purl.uniprot.org/core/author | "Katz D.H."xsd:string |
| http://purl.uniprot.org/citations/8144928 | http://purl.uniprot.org/core/date | "1994"xsd:gYear |
| http://purl.uniprot.org/citations/8144928 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/8144928 | http://purl.uniprot.org/core/pages | "3453-3466"xsd:string |
| http://purl.uniprot.org/citations/8144928 | http://purl.uniprot.org/core/title | "Regulation of the murine Fc epsilon RII (CD23) gene. Functional characterization of an IL-4 enhancer element."xsd:string |
| http://purl.uniprot.org/citations/8144928 | http://purl.uniprot.org/core/volume | "152"xsd:string |
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