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| http://purl.uniprot.org/citations/8160017 | http://www.w3.org/2000/01/rdf-schema#comment | "Transgenic mice were created with cardiac-specific overexpression of the beta 2-adrenergic receptor. This resulted in increased basal myocardial adenylyl cyclase activity, enhanced atrial contractility, and increased left ventricular function in vivo; these parameters at baseline in the transgenic animals were equal to those observed in control animals maximally stimulated with isoproterenol. These results illustrate a useful approach for studying the effect of gene expression on cardiac contractility. Because chronic heart failure in humans is accompanied by a reduction in the number of myocardial beta-adrenergic receptors and in inotropic responsiveness, these results suggest a potential gene therapy approach to this disease state."xsd:string |
| http://purl.uniprot.org/citations/8160017 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.8160017"xsd:string |
| http://purl.uniprot.org/citations/8160017 | http://purl.uniprot.org/core/author | "Lefkowitz R.J."xsd:string |
| http://purl.uniprot.org/citations/8160017 | http://purl.uniprot.org/core/author | "Allen L.F."xsd:string |
| http://purl.uniprot.org/citations/8160017 | http://purl.uniprot.org/core/author | "Rockman H.A."xsd:string |
| http://purl.uniprot.org/citations/8160017 | http://purl.uniprot.org/core/author | "Chien K.R."xsd:string |
| http://purl.uniprot.org/citations/8160017 | http://purl.uniprot.org/core/author | "Bond R.A."xsd:string |
| http://purl.uniprot.org/citations/8160017 | http://purl.uniprot.org/core/author | "Milano C.A."xsd:string |
| http://purl.uniprot.org/citations/8160017 | http://purl.uniprot.org/core/author | "Dolber P.C."xsd:string |
| http://purl.uniprot.org/citations/8160017 | http://purl.uniprot.org/core/author | "Johnson T.D."xsd:string |
| http://purl.uniprot.org/citations/8160017 | http://purl.uniprot.org/core/author | "McMinn T.R."xsd:string |
| http://purl.uniprot.org/citations/8160017 | http://purl.uniprot.org/core/date | "1994"xsd:gYear |
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| http://purl.uniprot.org/citations/8160017 | http://purl.uniprot.org/core/pages | "582-586"xsd:string |
| http://purl.uniprot.org/citations/8160017 | http://purl.uniprot.org/core/title | "Enhanced myocardial function in transgenic mice overexpressing the beta 2-adrenergic receptor."xsd:string |
| http://purl.uniprot.org/citations/8160017 | http://purl.uniprot.org/core/volume | "264"xsd:string |
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