| http://purl.uniprot.org/citations/8163536 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8163536 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8163536 | http://www.w3.org/2000/01/rdf-schema#comment | "B cell antigen receptors are multicomponent complexes consisting of the surface immunoglobulin and accessory molecules with associating protein-tyrosine kinases. A spleen tyrosine kinase, Syk, in porcine B cells and a 72-kDa protein-tyrosine kinase, PTK72, in murine B cells associate with the B cell antigen receptor. Herein, we report the isolation of a full-length cDNA encoding the human homologue of Syk. This cDNA predicted a polypeptide consisting of two NH2-terminal SH2 domains and a COOH-terminal tyrosine kinase domain. Syk is highly conserved between human and swine and is homologous to the T cell-associated protein-tyrosine kinase ZAP-70. Both Syk mRNA and protein were detected in cells derived from multiple hematopoietic lineages. Within the B cell compartment, Syk was expressed from pro-B cells to plasma cells. In vitro kinase assays conducted on the human Syk protein isolated from B cells revealed the presence of autophosphorylation activity on Syk tyrosine residues. Tyrosine phosphorylation of Syk associating with the B cell receptor complex in human was augmented rapidly after surface immunoglobulin cross-linking. The human SYK locus was mapped to chromosome 9 at band q22."xsd:string |
| http://purl.uniprot.org/citations/8163536 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0021-9258(17)32717-5"xsd:string |
| http://purl.uniprot.org/citations/8163536 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0021-9258(17)32717-5"xsd:string |
| http://purl.uniprot.org/citations/8163536 | http://purl.uniprot.org/core/author | "Disteche C.M."xsd:string |
| http://purl.uniprot.org/citations/8163536 | http://purl.uniprot.org/core/author | "Disteche C.M."xsd:string |
| http://purl.uniprot.org/citations/8163536 | http://purl.uniprot.org/core/author | "Edelhoff S."xsd:string |
| http://purl.uniprot.org/citations/8163536 | http://purl.uniprot.org/core/author | "Edelhoff S."xsd:string |
| http://purl.uniprot.org/citations/8163536 | http://purl.uniprot.org/core/author | "Weiss A."xsd:string |
| http://purl.uniprot.org/citations/8163536 | http://purl.uniprot.org/core/author | "Weiss A."xsd:string |
| http://purl.uniprot.org/citations/8163536 | http://purl.uniprot.org/core/author | "Law C.-L."xsd:string |
| http://purl.uniprot.org/citations/8163536 | http://purl.uniprot.org/core/author | "Law C.-L."xsd:string |
| http://purl.uniprot.org/citations/8163536 | http://purl.uniprot.org/core/author | "Chan A.C."xsd:string |
| http://purl.uniprot.org/citations/8163536 | http://purl.uniprot.org/core/author | "Chan A.C."xsd:string |
| http://purl.uniprot.org/citations/8163536 | http://purl.uniprot.org/core/author | "Clark E.A."xsd:string |
| http://purl.uniprot.org/citations/8163536 | http://purl.uniprot.org/core/author | "Clark E.A."xsd:string |
| http://purl.uniprot.org/citations/8163536 | http://purl.uniprot.org/core/author | "Chandran K.A."xsd:string |
| http://purl.uniprot.org/citations/8163536 | http://purl.uniprot.org/core/author | "Chandran K.A."xsd:string |
| http://purl.uniprot.org/citations/8163536 | http://purl.uniprot.org/core/author | "Sidorenko S.P."xsd:string |
| http://purl.uniprot.org/citations/8163536 | http://purl.uniprot.org/core/author | "Sidorenko S.P."xsd:string |
| http://purl.uniprot.org/citations/8163536 | http://purl.uniprot.org/core/author | "Draves K.E."xsd:string |
| http://purl.uniprot.org/citations/8163536 | http://purl.uniprot.org/core/author | "Draves K.E."xsd:string |
| http://purl.uniprot.org/citations/8163536 | http://purl.uniprot.org/core/date | "1994"xsd:gYear |
| http://purl.uniprot.org/citations/8163536 | http://purl.uniprot.org/core/date | "1994"xsd:gYear |