| http://purl.uniprot.org/citations/8179012 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8179012 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8179012 | http://www.w3.org/2000/01/rdf-schema#comment | "In the present study, we have characterized the mRNA transcripts and intron-exon organization of the human surfactant protein (SP)A1 and SP-A2 genes. By primer extension analysis of mRNA isolated from human fetal lung explants using an oligonucleotide primer to exon II (as delineated in the SP-A1 gene), a minimum of nine primer extended transcripts was observed. Rapid amplification of cDNA ends was used to amplify the primer extended transcripts for sequence analysis. Sequence analysis of 47 full-length primer extended cDNAs and comparison with the sequences of the genes encoding SP-A1 and SP-A2 revealed four different classes of transcripts of the SP-A2 gene and five different classes of transcripts of the gene encoding SP-A1. A major difference between SP-A2 and SP-A1 mRNA transcripts is that SP-A2 transcripts are always comprised of sequences contained within six exons; the extra exon in SP-A2 (exon II of VI) encodes additional 5'-untranslated sequence and is located between exons I and II of SP-A1. By contrast, the majority of transcripts of the SP-A1 gene are comprised of sequences contained within five exons. In the cases of both SP-A1 and SP-A2 genes, a small proportion of the mRNA transcripts contain sequences present in alternate exons. In addition, the majority of the SP-A1 mRNA transcripts are initiated 5 bp downstream of the transcription initiation site of SP-A2. In our companion paper [McCormick and Mendelson. Am. J. Physiol. 266 (Lung Cell. Mol. Physiol. 10): L367-L374, 1994], we report that the SP-A1 and SP-A2 genes are differentially regulated during development and by adenosine 3',5'-cyclic monophosphate and glucocorticoids in human fetal lung in culture."xsd:string |
| http://purl.uniprot.org/citations/8179012 | http://purl.org/dc/terms/identifier | "doi:10.1152/ajplung.1994.266.4.l354"xsd:string |
| http://purl.uniprot.org/citations/8179012 | http://purl.uniprot.org/core/author | "McCormick S.M."xsd:string |
| http://purl.uniprot.org/citations/8179012 | http://purl.uniprot.org/core/author | "McCormick S.M."xsd:string |
| http://purl.uniprot.org/citations/8179012 | http://purl.uniprot.org/core/author | "Boggaram V."xsd:string |
| http://purl.uniprot.org/citations/8179012 | http://purl.uniprot.org/core/author | "Boggaram V."xsd:string |
| http://purl.uniprot.org/citations/8179012 | http://purl.uniprot.org/core/author | "Mendelson C.R."xsd:string |
| http://purl.uniprot.org/citations/8179012 | http://purl.uniprot.org/core/author | "Mendelson C.R."xsd:string |
| http://purl.uniprot.org/citations/8179012 | http://purl.uniprot.org/core/date | "1994"xsd:gYear |
| http://purl.uniprot.org/citations/8179012 | http://purl.uniprot.org/core/date | "1994"xsd:gYear |
| http://purl.uniprot.org/citations/8179012 | http://purl.uniprot.org/core/name | "Am. J. Physiol."xsd:string |
| http://purl.uniprot.org/citations/8179012 | http://purl.uniprot.org/core/name | "Am J Physiol"xsd:string |
| http://purl.uniprot.org/citations/8179012 | http://purl.uniprot.org/core/pages | "L354-66"xsd:string |
| http://purl.uniprot.org/citations/8179012 | http://purl.uniprot.org/core/title | "Characterization of mRNA transcripts and organization of human SP-A1 and SP-A2 genes."xsd:string |
| http://purl.uniprot.org/citations/8179012 | http://purl.uniprot.org/core/title | "Characterization of mRNA transcripts and organization of human SP-A1 and SP-A2 genes."xsd:string |
| http://purl.uniprot.org/citations/8179012 | http://purl.uniprot.org/core/volume | "266"xsd:string |
| http://purl.uniprot.org/citations/8179012 | http://purl.uniprot.org/core/volume | "266"xsd:string |
| http://purl.uniprot.org/citations/8179012 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8179012 |
| http://purl.uniprot.org/citations/8179012 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8179012 |
| http://purl.uniprot.org/citations/8179012 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/8179012 |
| http://purl.uniprot.org/citations/8179012 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/8179012 |
| http://purl.uniprot.org/uniprot/P78490 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/8179012 |
| http://purl.uniprot.org/uniprot/Q16140 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/8179012 |