| http://purl.uniprot.org/citations/8183939 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8183939 | http://www.w3.org/2000/01/rdf-schema#comment | "The Krüppel-associated box (KRAB) is a highly conserved, 75-aa region containing two predicted amphipathic alpha-helices. The KRAB domain is present in the amino-terminal regions of more than one-third of all Krüppel-class Cys2His2 zinc finger proteins and is conserved from yeast to man; however, its function is unknown. Here it is shown that the KRAB domain functions as a DNA binding-dependent transcriptional repressor when fused to a heterologous DNA-binding domain from the yeast GAL4 protein. A 45-aa segment containing one of the predicted KRAB amphipathic helices was necessary and sufficient for repression. Amino acid substitutions in the predicted helix abolished the repression function. These results assign a function, transcriptional repression, to the highly conserved KRAB box and define a minimal repression domain which may aid in identifying mechanisms of repression."xsd:string |
| http://purl.uniprot.org/citations/8183939 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.91.10.4509"xsd:string |
| http://purl.uniprot.org/citations/8183939 | http://purl.uniprot.org/core/author | "Friedman J.R."xsd:string |
| http://purl.uniprot.org/citations/8183939 | http://purl.uniprot.org/core/author | "Margolin J.F."xsd:string |
| http://purl.uniprot.org/citations/8183939 | http://purl.uniprot.org/core/author | "Vissing H."xsd:string |
| http://purl.uniprot.org/citations/8183939 | http://purl.uniprot.org/core/author | "Thiesen H.J."xsd:string |
| http://purl.uniprot.org/citations/8183939 | http://purl.uniprot.org/core/author | "Rauscher F.J."xsd:string |
| http://purl.uniprot.org/citations/8183939 | http://purl.uniprot.org/core/author | "Meyer W.K."xsd:string |
| http://purl.uniprot.org/citations/8183939 | http://purl.uniprot.org/core/date | "1994"xsd:gYear |
| http://purl.uniprot.org/citations/8183939 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/8183939 | http://purl.uniprot.org/core/pages | "4509-4513"xsd:string |
| http://purl.uniprot.org/citations/8183939 | http://purl.uniprot.org/core/title | "Kruppel-associated boxes are potent transcriptional repression domains."xsd:string |
| http://purl.uniprot.org/citations/8183939 | http://purl.uniprot.org/core/volume | "91"xsd:string |
| http://purl.uniprot.org/citations/8183939 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8183939 |
| http://purl.uniprot.org/citations/8183939 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/8183939 |
| http://purl.uniprot.org/uniprot/#_P0C7X2-mappedCitation-8183939 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8183939 |
| http://purl.uniprot.org/uniprot/#_P0CB33-mappedCitation-8183939 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8183939 |
| http://purl.uniprot.org/uniprot/#_P52736-mappedCitation-8183939 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8183939 |
| http://purl.uniprot.org/uniprot/#_P52737-mappedCitation-8183939 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8183939 |
| http://purl.uniprot.org/uniprot/#_P52738-mappedCitation-8183939 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8183939 |
| http://purl.uniprot.org/uniprot/#_P52742-mappedCitation-8183939 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8183939 |
| http://purl.uniprot.org/uniprot/#_P52744-mappedCitation-8183939 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8183939 |
| http://purl.uniprot.org/uniprot/#_A4D1E1-mappedCitation-8183939 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8183939 |
| http://purl.uniprot.org/uniprot/#_A5PL33-mappedCitation-8183939 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8183939 |