| http://purl.uniprot.org/citations/8190122 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8190122 | http://www.w3.org/2000/01/rdf-schema#comment | "Inbred mouse strains vary in susceptibility or resistance to dietary induced atherosclerosis. To investigate the effect of polyunsaturated fat feeding on postprandial serum cholesterol levels, in C57BL/67 (B6) and BALB/cJ inbred mice, we fed by stomach gavage previously fasted mice, a mixture containing 30% sunflower oil, 5% cholesterol, 2% sodium cholate and 0.5% choline chloride. The most significant difference in serum cholesterol levels between B6 and BALB/cJ mouse strains was observed at 2 h postfeeding. Susceptible B6 strain mice had a 41% postprandial increment in serum cholesterol. The resistant BALB/cJ strain had an insignificant 16% rise in serum cholesterol, at 2 h. We next examined eight other inbred mouse strains, to identify the gene(s) that regulate the observed 2 h postprandial hypercholesterolemia response, in the susceptible B6 mouse strain. Only the C57BR/cdJ and C57L/J strains developed postprandial hypercholesterolemia, at 2 h. The C57BR/cdJ strain had a 20% increase and the C57L/J strain a 62% increase in postprandial serum cholesterol levels. From this result, we found that the postprandial hypercholesterolemic response to an acute polyunsaturated fat-cholesterol feed, cosegregated with the a allele at the Gpd-1 and Ahd-1 loci, on mouse chromosome 4. In this study, non-responsiveness cosegregated with the b allele at the Gpd-1 and Ahd-1 loci. Thus polyunsaturated fat-cholesterol induced postprandial hypercholesterolemia appeared to be genetically determined by a gene located between the Gpd-1 and Ahd-1 loci, in mice. The putative gene regulating polyunsaturated fat-cholesterol induced post-absorptive hypercholesterolemia was designated Phc-2.(ABSTRACT TRUNCATED AT 250 WORDS)"xsd:string |
| http://purl.uniprot.org/citations/8190122 | http://purl.org/dc/terms/identifier | "doi:10.1007/bf01084269"xsd:string |
| http://purl.uniprot.org/citations/8190122 | http://purl.uniprot.org/core/author | "Antao V."xsd:string |
| http://purl.uniprot.org/citations/8190122 | http://purl.uniprot.org/core/author | "Kakis G."xsd:string |
| http://purl.uniprot.org/citations/8190122 | http://purl.uniprot.org/core/author | "Vaithilingam D.S."xsd:string |
| http://purl.uniprot.org/citations/8190122 | http://purl.uniprot.org/core/date | "1994"xsd:gYear |
| http://purl.uniprot.org/citations/8190122 | http://purl.uniprot.org/core/name | "Mol Cell Biochem"xsd:string |
| http://purl.uniprot.org/citations/8190122 | http://purl.uniprot.org/core/pages | "67-74"xsd:string |
| http://purl.uniprot.org/citations/8190122 | http://purl.uniprot.org/core/title | "Regulation of polyunsaturated fat induced postprandial hypercholesterolemia by a novel gene Phc-2."xsd:string |
| http://purl.uniprot.org/citations/8190122 | http://purl.uniprot.org/core/volume | "130"xsd:string |
| http://purl.uniprot.org/citations/8190122 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8190122 |
| http://purl.uniprot.org/citations/8190122 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/8190122 |
| http://purl.uniprot.org/uniprot/#_A2A7A7-mappedCitation-8190122 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8190122 |
| http://purl.uniprot.org/uniprot/#_A2A7A8-mappedCitation-8190122 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8190122 |
| http://purl.uniprot.org/uniprot/#_Q8BU44-mappedCitation-8190122 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8190122 |
| http://purl.uniprot.org/uniprot/#_Q3TFM8-mappedCitation-8190122 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8190122 |
| http://purl.uniprot.org/uniprot/#_Q8CHT0-mappedCitation-8190122 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8190122 |
| http://purl.uniprot.org/uniprot/#_Q6P9Q7-mappedCitation-8190122 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8190122 |
| http://purl.uniprot.org/uniprot/#_Q8BMC8-mappedCitation-8190122 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8190122 |
| http://purl.uniprot.org/uniprot/#_Q8CFX1-mappedCitation-8190122 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8190122 |
| http://purl.uniprot.org/uniprot/#_Q8QZU3-mappedCitation-8190122 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8190122 |
| http://purl.uniprot.org/uniprot/Q8BMC8 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/8190122 |
| http://purl.uniprot.org/uniprot/Q6P9Q7 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/8190122 |
| http://purl.uniprot.org/uniprot/Q3TFM8 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/8190122 |