| http://purl.uniprot.org/citations/8194536 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8194536 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8194536 | http://www.w3.org/2000/01/rdf-schema#comment | "A Bacillus subtilis mutant spnA95 was isolated as resistant at 30 degrees C to the protein kinase C (PKC) inhibitor, sphinganine, and temperature sensitive for growth. As deduced by flow cytometry measurements, the mutant has a 35% reduced initiation mass at permissive temperature, resulting in initiation of DNA replication much earlier in the cell cycle than in the wild type. This modification is accompanied by a change in cell size, as determined by phase-contrast microscopy and flow cytometry. Therefore, this strain displays the characteristics of a novel cell clock mutant. spnA is a newly identified gene in B.subtilis and was shown to encode a cysteinyl-tRNA synthetase. At non-permissive temperature, the mutant was defective in the synthesis of P70, a protein with several characteristics of PKC (a cysteine-rich protein). As one possibility, we propose that the altered timing of replication may be due to the reduced synthesis of specific cysteine-rich proteins normally involved in controlling chromosomal replication initiation in B. subtilis."xsd:string |
| http://purl.uniprot.org/citations/8194536 | http://purl.org/dc/terms/identifier | "doi:10.1002/j.1460-2075.1994.tb06532.x"xsd:string |
| http://purl.uniprot.org/citations/8194536 | http://purl.org/dc/terms/identifier | "doi:10.1002/j.1460-2075.1994.tb06532.x"xsd:string |
| http://purl.uniprot.org/citations/8194536 | http://purl.uniprot.org/core/author | "Seror S.J."xsd:string |
| http://purl.uniprot.org/citations/8194536 | http://purl.uniprot.org/core/author | "Seror S.J."xsd:string |
| http://purl.uniprot.org/citations/8194536 | http://purl.uniprot.org/core/author | "Vannier F."xsd:string |
| http://purl.uniprot.org/citations/8194536 | http://purl.uniprot.org/core/author | "Vannier F."xsd:string |
| http://purl.uniprot.org/citations/8194536 | http://purl.uniprot.org/core/author | "Casaregola S."xsd:string |
| http://purl.uniprot.org/citations/8194536 | http://purl.uniprot.org/core/author | "Casaregola S."xsd:string |
| http://purl.uniprot.org/citations/8194536 | http://purl.uniprot.org/core/author | "Boye E."xsd:string |
| http://purl.uniprot.org/citations/8194536 | http://purl.uniprot.org/core/author | "Boye E."xsd:string |
| http://purl.uniprot.org/citations/8194536 | http://purl.uniprot.org/core/author | "Zouari N."xsd:string |
| http://purl.uniprot.org/citations/8194536 | http://purl.uniprot.org/core/author | "Zouari N."xsd:string |
| http://purl.uniprot.org/citations/8194536 | http://purl.uniprot.org/core/author | "Dahl M."xsd:string |
| http://purl.uniprot.org/citations/8194536 | http://purl.uniprot.org/core/author | "Dahl M."xsd:string |
| http://purl.uniprot.org/citations/8194536 | http://purl.uniprot.org/core/date | "1994"xsd:gYear |
| http://purl.uniprot.org/citations/8194536 | http://purl.uniprot.org/core/date | "1994"xsd:gYear |
| http://purl.uniprot.org/citations/8194536 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/8194536 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/8194536 | http://purl.uniprot.org/core/pages | "2472-2480"xsd:string |
| http://purl.uniprot.org/citations/8194536 | http://purl.uniprot.org/core/pages | "2472-2480"xsd:string |
| http://purl.uniprot.org/citations/8194536 | http://purl.uniprot.org/core/title | "A mutant cysteinyl-tRNA synthetase affecting timing of chromosomal replication initiation in B. subtilis and conferring resistance to a protein kinase C inhibitor."xsd:string |
| http://purl.uniprot.org/citations/8194536 | http://purl.uniprot.org/core/title | "A mutant cysteinyl-tRNA synthetase affecting timing of chromosomal replication initiation in B. subtilis and conferring resistance to a protein kinase C inhibitor."xsd:string |