| http://purl.uniprot.org/citations/8202159 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8202159 | http://www.w3.org/2000/01/rdf-schema#comment | "The development of blood cells including expansion of megakaryocyte progenitor cells requires the interplay of marrow stromal cells and polypeptide cytokines. Recently, characterization of c-Mpl, the receptor encoded by the proto-oncogene c-mpl, revealed structural homology with the haematopoietic cytokine receptor family, and its involvement in megakaryocyte development. We report here that the ligand for c-Mpl is relatively lineage specific, works both alone and synergistically with early acting cytokines to support megakaryocyte colony formation, and acts at a late stage of development to increase megakaryocyte size, polyploidization and expression of differentiation markers. In vivo, c-Mpl ligand stimulates platelet production by greatly expanding marrow and splenic megakaryocytes and their progenitors, and by shifting the distribution of megakaryocyte ploidy to higher values. Thus, as c-Mpl ligand has the expected characteristics of the major regulator of megakaryocyte development, we propose that it be termed thrombopoietin."xsd:string |
| http://purl.uniprot.org/citations/8202159 | http://purl.org/dc/terms/identifier | "doi:10.1038/369568a0"xsd:string |
| http://purl.uniprot.org/citations/8202159 | http://purl.uniprot.org/core/author | "Lok S."xsd:string |
| http://purl.uniprot.org/citations/8202159 | http://purl.uniprot.org/core/author | "Hagen F.S."xsd:string |
| http://purl.uniprot.org/citations/8202159 | http://purl.uniprot.org/core/author | "Forstrom J.W."xsd:string |
| http://purl.uniprot.org/citations/8202159 | http://purl.uniprot.org/core/author | "Kaushansky K."xsd:string |
| http://purl.uniprot.org/citations/8202159 | http://purl.uniprot.org/core/author | "Lin N."xsd:string |
| http://purl.uniprot.org/citations/8202159 | http://purl.uniprot.org/core/author | "Oort P.J."xsd:string |
| http://purl.uniprot.org/citations/8202159 | http://purl.uniprot.org/core/author | "Holly R.D."xsd:string |
| http://purl.uniprot.org/citations/8202159 | http://purl.uniprot.org/core/author | "Broudy V.C."xsd:string |
| http://purl.uniprot.org/citations/8202159 | http://purl.uniprot.org/core/author | "Buddle M.M."xsd:string |
| http://purl.uniprot.org/citations/8202159 | http://purl.uniprot.org/core/author | "Bailey M.C."xsd:string |
| http://purl.uniprot.org/citations/8202159 | http://purl.uniprot.org/core/date | "1994"xsd:gYear |
| http://purl.uniprot.org/citations/8202159 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/8202159 | http://purl.uniprot.org/core/pages | "568-571"xsd:string |
| http://purl.uniprot.org/citations/8202159 | http://purl.uniprot.org/core/title | "Promotion of megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand thrombopoietin."xsd:string |
| http://purl.uniprot.org/citations/8202159 | http://purl.uniprot.org/core/volume | "369"xsd:string |
| http://purl.uniprot.org/citations/8202159 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8202159 |
| http://purl.uniprot.org/citations/8202159 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/8202159 |
| http://purl.uniprot.org/citations/8202159 | http://purl.uniprot.org/core/authorsIncomplete | "true"xsd:boolean |
| http://purl.uniprot.org/uniprot/P40225#attribution-04072A988F27D95231CB648185F116DB | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/8202159 |
| http://purl.uniprot.org/uniprot/P40225#attribution-CE870EB4E5A5B54ACA3306656384CC0A | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/8202159 |