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http://purl.uniprot.org/citations/8202713http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/8202713http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/8202713http://www.w3.org/2000/01/rdf-schema#comment"Protein tyrosine kinases (PTKs) play an integral role in T cell activation and differentiation. Defects in the Src-family PTKs in mice and in T cell lines have resulted in variable defects in thymic development and in T cell antigen receptor (TCR) signal transduction. Here, three siblings are described with an autosomal recessive form of severe combined immunodeficiency disease (SCID) in which ZAP-70, a non-Src PTK, is absent as a result of mutations in the ZAP-70 gene. This absence is associated with defects in TCR signal transduction, suggesting an important functional role for ZAP-70."xsd:string
http://purl.uniprot.org/citations/8202713http://purl.org/dc/terms/identifier"doi:10.1126/science.8202713"xsd:string
http://purl.uniprot.org/citations/8202713http://purl.org/dc/terms/identifier"doi:10.1126/science.8202713"xsd:string
http://purl.uniprot.org/citations/8202713http://purl.uniprot.org/core/author"Parslow T.G."xsd:string
http://purl.uniprot.org/citations/8202713http://purl.uniprot.org/core/author"Parslow T.G."xsd:string
http://purl.uniprot.org/citations/8202713http://purl.uniprot.org/core/author"Weiss A."xsd:string
http://purl.uniprot.org/citations/8202713http://purl.uniprot.org/core/author"Weiss A."xsd:string
http://purl.uniprot.org/citations/8202713http://purl.uniprot.org/core/author"Kuo W.-L."xsd:string
http://purl.uniprot.org/citations/8202713http://purl.uniprot.org/core/author"Kuo W.-L."xsd:string
http://purl.uniprot.org/citations/8202713http://purl.uniprot.org/core/author"Chan A.C."xsd:string
http://purl.uniprot.org/citations/8202713http://purl.uniprot.org/core/author"Chan A.C."xsd:string
http://purl.uniprot.org/citations/8202713http://purl.uniprot.org/core/author"Iwashima M."xsd:string
http://purl.uniprot.org/citations/8202713http://purl.uniprot.org/core/author"Iwashima M."xsd:string
http://purl.uniprot.org/citations/8202713http://purl.uniprot.org/core/author"Kadlecek T.A."xsd:string
http://purl.uniprot.org/citations/8202713http://purl.uniprot.org/core/author"Kadlecek T.A."xsd:string
http://purl.uniprot.org/citations/8202713http://purl.uniprot.org/core/author"Elder M.E."xsd:string
http://purl.uniprot.org/citations/8202713http://purl.uniprot.org/core/author"Elder M.E."xsd:string
http://purl.uniprot.org/citations/8202713http://purl.uniprot.org/core/author"Filipovich A.H."xsd:string
http://purl.uniprot.org/citations/8202713http://purl.uniprot.org/core/author"Filipovich A.H."xsd:string
http://purl.uniprot.org/citations/8202713http://purl.uniprot.org/core/date"1994"xsd:gYear
http://purl.uniprot.org/citations/8202713http://purl.uniprot.org/core/date"1994"xsd:gYear
http://purl.uniprot.org/citations/8202713http://purl.uniprot.org/core/name"Science"xsd:string
http://purl.uniprot.org/citations/8202713http://purl.uniprot.org/core/name"Science"xsd:string