| http://purl.uniprot.org/citations/8206964 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8206964 | http://www.w3.org/2000/01/rdf-schema#comment | "Bcl-2 is an integral membrane protein that functions as a suppressor of programmed cell death. It contains a COOH-terminal signal anchor sequence that is selective for import and insertion of Bcl-2 into the mitochondrial outer membrane and, by a different mechanism, can also direct the protein to other membrane sites. Deletion of the signal anchor sequence rendered Bcl-2 cytosolic and impaired its ability to prevent apoptotic death of human KB cells infected with a mutant form of adenovirus type 5 that does not make E1B 19-kDa protein. When the predicted transmembrane domain of the Bcl-2 signal anchor was replaced with that of the signal anchor of the yeast outer mitochondrial membrane protein, Mas70p, the Bcl-2/Mas70p hybrid was found to be very similar to Bcl-2 in its distribution within transfected KB cells, in its ability to heterodimerize with Bax, and in its ability to suppress apoptosis. These results are consistent with a model in which the transmembrane segment contributes to the function of Bcl-2 by targeting and anchoring the protein to strategic membrane locations in the cell. Concentration of Bcl-2 at these sites may contribute to its proposed role as regulator, or component, of an antioxidant pathway."xsd:string |
| http://purl.uniprot.org/citations/8206964 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0021-9258(19)89417-6"xsd:string |
| http://purl.uniprot.org/citations/8206964 | http://purl.uniprot.org/core/author | "Nguyen M."xsd:string |
| http://purl.uniprot.org/citations/8206964 | http://purl.uniprot.org/core/author | "Branton P.E."xsd:string |
| http://purl.uniprot.org/citations/8206964 | http://purl.uniprot.org/core/author | "Shore G.C."xsd:string |
| http://purl.uniprot.org/citations/8206964 | http://purl.uniprot.org/core/author | "Korsmeyer S.J."xsd:string |
| http://purl.uniprot.org/citations/8206964 | http://purl.uniprot.org/core/author | "Oltvai Z.N."xsd:string |
| http://purl.uniprot.org/citations/8206964 | http://purl.uniprot.org/core/author | "Walton P.A."xsd:string |
| http://purl.uniprot.org/citations/8206964 | http://purl.uniprot.org/core/date | "1994"xsd:gYear |
| http://purl.uniprot.org/citations/8206964 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/8206964 | http://purl.uniprot.org/core/pages | "16521-16524"xsd:string |
| http://purl.uniprot.org/citations/8206964 | http://purl.uniprot.org/core/title | "Role of membrane anchor domain of Bcl-2 in suppression of apoptosis caused by E1B-defective adenovirus."xsd:string |
| http://purl.uniprot.org/citations/8206964 | http://purl.uniprot.org/core/volume | "269"xsd:string |
| http://purl.uniprot.org/citations/8206964 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8206964 |
| http://purl.uniprot.org/citations/8206964 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/8206964 |
| http://purl.uniprot.org/uniprot/#_P07213-mappedCitation-8206964 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8206964 |
| http://purl.uniprot.org/uniprot/P07213 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/8206964 |