| http://purl.uniprot.org/citations/8220435 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8220435 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8220435 | http://www.w3.org/2000/01/rdf-schema#comment | "Familial Alzheimer's disease (FAD) is a genetically heterogeneous disorder that includes a rare early-onset form linked to mutations in the amyloid b protein precursor (APP) gene. Clues to the function of APP derive from the recent finding that it is a member of a highly conserved protein family that includes the mammalian amyloid precursor-like protein (APLP1) gene which maps to the same general region of human chromosome 19 linked to late-onset FAD. Here we report the isolation of the human APLP2 gene. We show that APLP2 is a close relative of APP and exhibits a very similar pattern of expression in the brain and throughout the body. Like APP, APLP2 contains a cytoplasmic domain predicted to couple with the GTP-binding protein G(o) indicating that it may be an additional cell surface activator of this G protein."xsd:string |
| http://purl.uniprot.org/citations/8220435 | http://purl.org/dc/terms/identifier | "doi:10.1038/ng0993-95"xsd:string |
| http://purl.uniprot.org/citations/8220435 | http://purl.org/dc/terms/identifier | "doi:10.1038/ng0993-95"xsd:string |
| http://purl.uniprot.org/citations/8220435 | http://purl.uniprot.org/core/author | "Neve R.L."xsd:string |
| http://purl.uniprot.org/citations/8220435 | http://purl.uniprot.org/core/author | "Neve R.L."xsd:string |
| http://purl.uniprot.org/citations/8220435 | http://purl.uniprot.org/core/author | "Hyman B.T."xsd:string |
| http://purl.uniprot.org/citations/8220435 | http://purl.uniprot.org/core/author | "Hyman B.T."xsd:string |
| http://purl.uniprot.org/citations/8220435 | http://purl.uniprot.org/core/author | "Sisodia S.S."xsd:string |
| http://purl.uniprot.org/citations/8220435 | http://purl.uniprot.org/core/author | "Sisodia S.S."xsd:string |
| http://purl.uniprot.org/citations/8220435 | http://purl.uniprot.org/core/author | "Tanzi R.E."xsd:string |
| http://purl.uniprot.org/citations/8220435 | http://purl.uniprot.org/core/author | "Tanzi R.E."xsd:string |
| http://purl.uniprot.org/citations/8220435 | http://purl.uniprot.org/core/author | "Wasco W."xsd:string |
| http://purl.uniprot.org/citations/8220435 | http://purl.uniprot.org/core/author | "Wasco W."xsd:string |
| http://purl.uniprot.org/citations/8220435 | http://purl.uniprot.org/core/author | "Romano D.M."xsd:string |
| http://purl.uniprot.org/citations/8220435 | http://purl.uniprot.org/core/author | "Romano D.M."xsd:string |
| http://purl.uniprot.org/citations/8220435 | http://purl.uniprot.org/core/author | "Gurubhagavatula S."xsd:string |
| http://purl.uniprot.org/citations/8220435 | http://purl.uniprot.org/core/author | "Gurubhagavatula S."xsd:string |
| http://purl.uniprot.org/citations/8220435 | http://purl.uniprot.org/core/author | "Paradis M."xsd:string |
| http://purl.uniprot.org/citations/8220435 | http://purl.uniprot.org/core/author | "Paradis M."xsd:string |
| http://purl.uniprot.org/citations/8220435 | http://purl.uniprot.org/core/date | "1993"xsd:gYear |
| http://purl.uniprot.org/citations/8220435 | http://purl.uniprot.org/core/date | "1993"xsd:gYear |
| http://purl.uniprot.org/citations/8220435 | http://purl.uniprot.org/core/name | "Nat. Genet."xsd:string |
| http://purl.uniprot.org/citations/8220435 | http://purl.uniprot.org/core/name | "Nat. Genet."xsd:string |