| http://purl.uniprot.org/citations/8228801 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8228801 | http://www.w3.org/2000/01/rdf-schema#comment | "Interleukin 10 (IL-10) has recently been shown to induce normal human B lymphocytes to proliferate and differentiate into immunoglobulin (Ig)-secreting cells. Herein, we show that IL-10 also promotes DNA synthesis and IgM production by anti-CD40 activated B cell chronic lymphocytic leukemia (B-CLL). Most strikingly, IL-2 and IL-10 were found to synergize to induce the proliferation and differentiation of B-CLL cells. This synergy between IL-2 and IL-10 was also observed with normal B cells which proliferated strongly and secreted large amounts of IgM, IgG, and IgA. The observed synergy is likely to be due to the IL-10-induced increase of high affinity IL-2 receptors on both normal and leukemic B cells. This increase of high affinity receptor is associated to an increase of Tac/CD25 expression that can be detected by flow cytometric analysis. Taken together, these results indicate that IL-10 permits anti-CD40 activated B cells to respond to IL-2 through an induction of high affinity IL-2 receptors. This effect of IL-10 may partly explain how T cells, which activate B cells in a CD40-dependent fashion, induce B cell proliferation and differentiation mostly through IL-2."xsd:string |
| http://purl.uniprot.org/citations/8228801 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.178.5.1473"xsd:string |
| http://purl.uniprot.org/citations/8228801 | http://purl.uniprot.org/core/author | "Durand I."xsd:string |
| http://purl.uniprot.org/citations/8228801 | http://purl.uniprot.org/core/author | "Fluckiger A.C."xsd:string |
| http://purl.uniprot.org/citations/8228801 | http://purl.uniprot.org/core/author | "Banchereau J."xsd:string |
| http://purl.uniprot.org/citations/8228801 | http://purl.uniprot.org/core/author | "Garrone P."xsd:string |
| http://purl.uniprot.org/citations/8228801 | http://purl.uniprot.org/core/author | "Galizzi J.P."xsd:string |
| http://purl.uniprot.org/citations/8228801 | http://purl.uniprot.org/core/date | "1993"xsd:gYear |
| http://purl.uniprot.org/citations/8228801 | http://purl.uniprot.org/core/name | "J Exp Med"xsd:string |
| http://purl.uniprot.org/citations/8228801 | http://purl.uniprot.org/core/pages | "1473-1481"xsd:string |
| http://purl.uniprot.org/citations/8228801 | http://purl.uniprot.org/core/title | "Interleukin 10 (IL-10) upregulates functional high affinity IL-2 receptors on normal and leukemic B lymphocytes."xsd:string |
| http://purl.uniprot.org/citations/8228801 | http://purl.uniprot.org/core/volume | "178"xsd:string |
| http://purl.uniprot.org/citations/8228801 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8228801 |
| http://purl.uniprot.org/citations/8228801 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/8228801 |
| http://purl.uniprot.org/uniprot/P22301#attribution-1EDF61C68B487DA5433119A0C3DF6FD9 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/8228801 |
| http://purl.uniprot.org/uniprot/#_A0A7R8GUQ3-mappedCitation-8228801 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8228801 |
| http://purl.uniprot.org/uniprot/#_Q3U879-mappedCitation-8228801 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8228801 |
| http://purl.uniprot.org/uniprot/#_P18893-mappedCitation-8228801 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8228801 |
| http://purl.uniprot.org/uniprot/A0A7R8GUQ3 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/8228801 |
| http://purl.uniprot.org/uniprot/P18893 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/8228801 |
| http://purl.uniprot.org/uniprot/Q3U879 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/8228801 |