| http://purl.uniprot.org/citations/8228830 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8228830 | http://www.w3.org/2000/01/rdf-schema#comment | "Experimental induction of most autoimmune diseases appears to depend on the activation of CD4+ T helper cells, while CD8+ lymphocytes may have a role in disease progression. To study the role of CD4+ and CD8+ T cell subsets in T cell-dependent autoimmunity, mice lacking CD4 or CD8 molecules after gene targeting were injected with cardiac myosin to induce organ specific autoimmune myocarditis. Mice homozygous for the CD8 mutation (CD8-/-) developed significantly more severe disease as compared to CD4+/-CD8+/-controls. Surprisingly, CD4-/-mice developed autoimmune myocarditis with infiltration of TCR alpha beta +CD4-CD8-T cells in the heart tissue and appearance of autoantibodies. These data demonstrate that the lack of CD4+ or CD8+ T cells has no significant influence on the initiation of autoimmune myocarditis. CD4+ and CD8+ cells regulate disease severity and these results may explain the occurrence of autoimmunity in CD4 immunodeficiencies."xsd:string |
| http://purl.uniprot.org/citations/8228830 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.178.5.1837"xsd:string |
| http://purl.uniprot.org/citations/8228830 | http://purl.uniprot.org/core/author | "Mak T.W."xsd:string |
| http://purl.uniprot.org/citations/8228830 | http://purl.uniprot.org/core/author | "Penninger J.M."xsd:string |
| http://purl.uniprot.org/citations/8228830 | http://purl.uniprot.org/core/author | "Kishihara K."xsd:string |
| http://purl.uniprot.org/citations/8228830 | http://purl.uniprot.org/core/author | "Timms E."xsd:string |
| http://purl.uniprot.org/citations/8228830 | http://purl.uniprot.org/core/author | "Wallace V.A."xsd:string |
| http://purl.uniprot.org/citations/8228830 | http://purl.uniprot.org/core/author | "Koh D.R."xsd:string |
| http://purl.uniprot.org/citations/8228830 | http://purl.uniprot.org/core/author | "Neu N."xsd:string |
| http://purl.uniprot.org/citations/8228830 | http://purl.uniprot.org/core/author | "Pummerer C."xsd:string |
| http://purl.uniprot.org/citations/8228830 | http://purl.uniprot.org/core/date | "1993"xsd:gYear |
| http://purl.uniprot.org/citations/8228830 | http://purl.uniprot.org/core/name | "J Exp Med"xsd:string |
| http://purl.uniprot.org/citations/8228830 | http://purl.uniprot.org/core/pages | "1837-1842"xsd:string |
| http://purl.uniprot.org/citations/8228830 | http://purl.uniprot.org/core/title | "The induction of experimental autoimmune myocarditis in mice lacking CD4 or CD8 molecules."xsd:string |
| http://purl.uniprot.org/citations/8228830 | http://purl.uniprot.org/core/volume | "178"xsd:string |
| http://purl.uniprot.org/citations/8228830 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8228830 |
| http://purl.uniprot.org/citations/8228830 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/8228830 |
| http://purl.uniprot.org/uniprot/#_P70443-mappedCitation-8228830 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8228830 |
| http://purl.uniprot.org/uniprot/#_A2MZG6-mappedCitation-8228830 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8228830 |
| http://purl.uniprot.org/uniprot/#_J3QMU3-mappedCitation-8228830 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8228830 |
| http://purl.uniprot.org/uniprot/#_P06332-mappedCitation-8228830 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8228830 |
| http://purl.uniprot.org/uniprot/#_F8WHM0-mappedCitation-8228830 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8228830 |
| http://purl.uniprot.org/uniprot/#_P01731-mappedCitation-8228830 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8228830 |
| http://purl.uniprot.org/uniprot/#_O55054-mappedCitation-8228830 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/8228830 |