| http://purl.uniprot.org/citations/8232210 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8232210 | http://www.w3.org/2000/01/rdf-schema#comment | "The vestigal (vg) gene encodes a nuclear protein which plays a major role in the formation of the wing of Drosophila. Resistance or sensitivity to aminopterin, an inhibitor of the dihydrofolate reductase enzyme in D. melanogaster, seems to be associated with a specific alteration in vg gene function. Wild-type and vg mutant strains selected for growth on increasing concentrations of aminopterin display changes in physiological and biochemical parameters such as viability on normal and aminopterin-containing media, duration of development, wing phenotype, dihydrofolate reductase activity, and cross-resistance to fluorodeoxyuridine (FUdR) and to methotrexate. Our results indicate that the mechanisms of resistance differ in the wild-type and mutant strains. The vg83b27 mutant, in which the major part of intron 2 of the vg gene is deleted, is associated with a high rate of resistance to FUdR, an inhibitor of thymidylate synthetase. Moreover, vg83b27/vgBG heterozygotes, which are wild type when grown on normal medium, display a strong vg phenotype when grown on aminopterin. Our results indicate a role for the vestigial locus in mediating resistance to inhibitors of dTMP synthesis."xsd:string |
| http://purl.uniprot.org/citations/8232210 | http://purl.org/dc/terms/identifier | "doi:10.1007/bf00280199"xsd:string |
| http://purl.uniprot.org/citations/8232210 | http://purl.uniprot.org/core/author | "Silber J."xsd:string |
| http://purl.uniprot.org/citations/8232210 | http://purl.uniprot.org/core/author | "Chevillard S."xsd:string |
| http://purl.uniprot.org/citations/8232210 | http://purl.uniprot.org/core/author | "Zider A."xsd:string |
| http://purl.uniprot.org/citations/8232210 | http://purl.uniprot.org/core/author | "Le Menn A."xsd:string |
| http://purl.uniprot.org/citations/8232210 | http://purl.uniprot.org/core/author | "Paumard S."xsd:string |
| http://purl.uniprot.org/citations/8232210 | http://purl.uniprot.org/core/date | "1993"xsd:gYear |
| http://purl.uniprot.org/citations/8232210 | http://purl.uniprot.org/core/name | "Mol Gen Genet"xsd:string |
| http://purl.uniprot.org/citations/8232210 | http://purl.uniprot.org/core/pages | "42-48"xsd:string |
| http://purl.uniprot.org/citations/8232210 | http://purl.uniprot.org/core/title | "The vestigial locus of Drosophila melanogaster is involved in resistance to inhibitors of dTMP synthesis."xsd:string |
| http://purl.uniprot.org/citations/8232210 | http://purl.uniprot.org/core/volume | "241"xsd:string |
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