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http://purl.uniprot.org/citations/8242740http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/8242740http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/8242740http://www.w3.org/2000/01/rdf-schema#comment"We have cloned the C. elegans cell death gene ced-3. A ced-3 transcript is most abundant during embryogenesis, the stage during which most programmed cell deaths occur. The predicted CED-3 protein shows similarity to human and murine interleukin-1 beta-converting enzyme and to the product of the mouse nedd-2 gene, which is expressed in the embryonic brain. The sequences of 12 ced-3 mutations as well as the sequences of ced-3 genes from two related nematode species identify sites of potential functional importance. We propose that the CED-3 protein acts as a cysteine protease in the initiation of programmed cell death in C. elegans and that cysteine proteases also function in programmed cell death in mammals."xsd:string
http://purl.uniprot.org/citations/8242740http://purl.org/dc/terms/identifier"doi:10.1016/0092-8674(93)90485-9"xsd:string
http://purl.uniprot.org/citations/8242740http://purl.org/dc/terms/identifier"doi:10.1016/0092-8674(93)90485-9"xsd:string
http://purl.uniprot.org/citations/8242740http://purl.uniprot.org/core/author"Horvitz H.R."xsd:string
http://purl.uniprot.org/citations/8242740http://purl.uniprot.org/core/author"Horvitz H.R."xsd:string
http://purl.uniprot.org/citations/8242740http://purl.uniprot.org/core/author"Yuan J."xsd:string
http://purl.uniprot.org/citations/8242740http://purl.uniprot.org/core/author"Yuan J."xsd:string
http://purl.uniprot.org/citations/8242740http://purl.uniprot.org/core/author"Shaham S."xsd:string
http://purl.uniprot.org/citations/8242740http://purl.uniprot.org/core/author"Shaham S."xsd:string
http://purl.uniprot.org/citations/8242740http://purl.uniprot.org/core/author"Ledoux S."xsd:string
http://purl.uniprot.org/citations/8242740http://purl.uniprot.org/core/author"Ledoux S."xsd:string
http://purl.uniprot.org/citations/8242740http://purl.uniprot.org/core/author"Ellis H.M."xsd:string
http://purl.uniprot.org/citations/8242740http://purl.uniprot.org/core/author"Ellis H.M."xsd:string
http://purl.uniprot.org/citations/8242740http://purl.uniprot.org/core/date"1993"xsd:gYear
http://purl.uniprot.org/citations/8242740http://purl.uniprot.org/core/date"1993"xsd:gYear
http://purl.uniprot.org/citations/8242740http://purl.uniprot.org/core/name"Cell"xsd:string
http://purl.uniprot.org/citations/8242740http://purl.uniprot.org/core/name"Cell"xsd:string
http://purl.uniprot.org/citations/8242740http://purl.uniprot.org/core/pages"641-652"xsd:string
http://purl.uniprot.org/citations/8242740http://purl.uniprot.org/core/pages"641-652"xsd:string
http://purl.uniprot.org/citations/8242740http://purl.uniprot.org/core/title"The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme."xsd:string
http://purl.uniprot.org/citations/8242740http://purl.uniprot.org/core/title"The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme."xsd:string
http://purl.uniprot.org/citations/8242740http://purl.uniprot.org/core/volume"75"xsd:string
http://purl.uniprot.org/citations/8242740http://purl.uniprot.org/core/volume"75"xsd:string