| http://purl.uniprot.org/citations/8264154 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8264154 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8264154 | http://www.w3.org/2000/01/rdf-schema#comment | "Central features of progressive glomerular sclerosis are initial glomerular hypertrophy and subsequent accumulation of extracellular matrix proteins. Since TGF-beta 1 may play a key role in this glomerular response to injury, the present study sought to explore further TGF-beta 1 actions and regulated expression of its receptor in rat mesangial cells. The rat TGF-beta type II receptor (TGF-beta RII) homolog was cloned by screening a rat kidney cDNA library with a human TGF-beta RII cDNA probe, and sequenced. Expression of this receptor subtype in rat mesangial cells was then demonstrated by RNase protection assay, and by Northern blot analysis of poly (A)+ RNA, TGF-beta RII expression was down-regulated in cells treated with exogenous TGF-beta 1. Affinity cross linking studies demonstrated presence of this receptor on cell surface. Rat mesangial cells also expressed TGF-beta 1 and autoinduction by TGF-beta 1 was observed in the same cells, suggesting that this polypeptide may act in an autocrine fashion on mesangial cells, and that it may stimulate a positive autoamplification loop. TGF-beta 1 inhibited mesangial cell proliferation and stimulated significant overall protein and collagen production. Furthermore, mesangial cell size increased in response to chronic TGF-beta 1 treatment. These findings demonstrate that rat mesangial cells express key components of the TGF-beta system and raise the intriguing possibility that in the glomerular mesangium, TGF-beta 1 may not only induce extracellular matrix synthesis, but may also participate in the process of glomerular hypertrophy in response to injury."xsd:string |
| http://purl.uniprot.org/citations/8264154 | http://purl.org/dc/terms/identifier | "doi:10.1038/ki.1993.336"xsd:string |
| http://purl.uniprot.org/citations/8264154 | http://purl.org/dc/terms/identifier | "doi:10.1038/ki.1993.336"xsd:string |
| http://purl.uniprot.org/citations/8264154 | http://purl.uniprot.org/core/author | "Huang Q."xsd:string |
| http://purl.uniprot.org/citations/8264154 | http://purl.uniprot.org/core/author | "Huang Q."xsd:string |
| http://purl.uniprot.org/citations/8264154 | http://purl.uniprot.org/core/author | "Ballermann B.J."xsd:string |
| http://purl.uniprot.org/citations/8264154 | http://purl.uniprot.org/core/author | "Ballermann B.J."xsd:string |
| http://purl.uniprot.org/citations/8264154 | http://purl.uniprot.org/core/author | "Kim E.G."xsd:string |
| http://purl.uniprot.org/citations/8264154 | http://purl.uniprot.org/core/author | "Kim E.G."xsd:string |
| http://purl.uniprot.org/citations/8264154 | http://purl.uniprot.org/core/author | "Choi M.E."xsd:string |
| http://purl.uniprot.org/citations/8264154 | http://purl.uniprot.org/core/author | "Choi M.E."xsd:string |
| http://purl.uniprot.org/citations/8264154 | http://purl.uniprot.org/core/date | "1993"xsd:gYear |
| http://purl.uniprot.org/citations/8264154 | http://purl.uniprot.org/core/date | "1993"xsd:gYear |
| http://purl.uniprot.org/citations/8264154 | http://purl.uniprot.org/core/name | "Kidney Int."xsd:string |
| http://purl.uniprot.org/citations/8264154 | http://purl.uniprot.org/core/name | "Kidney Int."xsd:string |
| http://purl.uniprot.org/citations/8264154 | http://purl.uniprot.org/core/pages | "948-958"xsd:string |
| http://purl.uniprot.org/citations/8264154 | http://purl.uniprot.org/core/pages | "948-958"xsd:string |
| http://purl.uniprot.org/citations/8264154 | http://purl.uniprot.org/core/title | "Rat mesangial cell hypertrophy in response to transforming growth factor-beta 1."xsd:string |
| http://purl.uniprot.org/citations/8264154 | http://purl.uniprot.org/core/title | "Rat mesangial cell hypertrophy in response to transforming growth factor-beta 1."xsd:string |
| http://purl.uniprot.org/citations/8264154 | http://purl.uniprot.org/core/volume | "44"xsd:string |
| http://purl.uniprot.org/citations/8264154 | http://purl.uniprot.org/core/volume | "44"xsd:string |
| http://purl.uniprot.org/citations/8264154 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8264154 |
| http://purl.uniprot.org/citations/8264154 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8264154 |