| http://purl.uniprot.org/citations/8264585 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8264585 | http://www.w3.org/2000/01/rdf-schema#comment | "Fibroblast growth factor (FGF) receptors (FGFRs) are structurally related receptor protein tyrosine kinases encoded by four distinct genes. Activation of FGFR-1, -2, and -3 by FGFs induces mitogenic responses in various cell types, but the mitogenic potential of FGFR-4 has not been previously explored. We have compared the properties of BaF3 murine lymphoid cells and L6 rat myoblast cells engineered to express FGFR-1 or FGFR-4. Acidic FGF binds with high affinity to and elicits tyrosine phosphorylation of FGFR-1 or FGFR-4 receptors displayed on BaF3 cells, but only FGFR-1 activation leads to cell survival and growth. FGFR-4 activation also fails to elicit detectable signals characteristic of the FGFR-1 response: tyrosine phosphorylation of SHC and extracellular signal-related kinase (ERK) proteins and induction of fos and tis11 RNA expression. The only detected response to FGFR-4 activation was weak phosphorylation of phospholipase C gamma. A chimeric receptor containing the extracellular domain of FGFR-4 and the intracellular domain of FGFR-1 confers FGF-dependent growth upon transfected BaF3 cells, demonstrating that the intracellular domains of the receptors dictate their functional capacity. Activation of FGFR-1 in transfected L6 myoblasts induced far stronger phosphorylation of phospholipase C gamma, SHC, and ERK proteins than could activation of FGFR-4 in L6 cells, and only FGFR-1 activation induced tyrosine phosphorylation of a characteristic 80-kD protein. Hence, the signaling and biological responses elicited by different FGF receptors substantially differ."xsd:string |
| http://purl.uniprot.org/citations/8264585 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.14.1.181-188.1994"xsd:string |
| http://purl.uniprot.org/citations/8264585 | http://purl.uniprot.org/core/author | "Gao G."xsd:string |
| http://purl.uniprot.org/citations/8264585 | http://purl.uniprot.org/core/author | "Goldfarb M."xsd:string |
| http://purl.uniprot.org/citations/8264585 | http://purl.uniprot.org/core/author | "Wang J.K."xsd:string |
| http://purl.uniprot.org/citations/8264585 | http://purl.uniprot.org/core/date | "1994"xsd:gYear |
| http://purl.uniprot.org/citations/8264585 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/8264585 | http://purl.uniprot.org/core/pages | "181-188"xsd:string |
| http://purl.uniprot.org/citations/8264585 | http://purl.uniprot.org/core/title | "Fibroblast growth factor receptors have different signaling and mitogenic potentials."xsd:string |
| http://purl.uniprot.org/citations/8264585 | http://purl.uniprot.org/core/volume | "14"xsd:string |
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