| http://purl.uniprot.org/citations/8268912 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8268912 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8268912 | http://www.w3.org/2000/01/rdf-schema#comment | "The proto-oncogene bmi-1 is frequently activated by Moloney murine leukemia proviral insertions in E mu-myc transgenic mice1,2. Using a mouse bmi-1 cDNA probe a transcript of 3.3 kb was detected on Northern blots of human Burkitt's lymphoma cell lines. We have isolated and sequenced cDNA clones from a human erythroleukemia cell line (K562) derived cDNA library, using different mouse bmi-1 cDNA fragments as a probe. Analysis of genomic BMI-1 sequences reveals a gene structure which is very similar to that of the mouse, consisting of at least 10 exons. The human cDNA is 3203 bp in length and shows 86% identity to the mouse nucleotide sequence. The open reading frame encodes a protein of 326 amino acids which shares 98% identity to the amino acid sequence of mouse bmi-1 protein. In vitro translation experiments show that human cDNA derived RNA translates into a protein with a mobility of 44-46 kD on SDS polyacrylamide gels. Fluorescence in situ hybridization (FISH) on metaphase chromosome spreads located the human BMI-1 gene to the short arm of chromosome 10 (10p13), a region known to be involved in translocations in various leukemias."xsd:string |
| http://purl.uniprot.org/citations/8268912 | http://purl.org/dc/terms/identifier | "doi:10.1093/hmg/2.10.1597"xsd:string |
| http://purl.uniprot.org/citations/8268912 | http://purl.org/dc/terms/identifier | "doi:10.1093/hmg/2.10.1597"xsd:string |
| http://purl.uniprot.org/citations/8268912 | http://purl.uniprot.org/core/author | "Berns A."xsd:string |
| http://purl.uniprot.org/citations/8268912 | http://purl.uniprot.org/core/author | "Berns A."xsd:string |
| http://purl.uniprot.org/citations/8268912 | http://purl.uniprot.org/core/author | "Alkema M.J."xsd:string |
| http://purl.uniprot.org/citations/8268912 | http://purl.uniprot.org/core/author | "Alkema M.J."xsd:string |
| http://purl.uniprot.org/citations/8268912 | http://purl.uniprot.org/core/author | "Raap A.K."xsd:string |
| http://purl.uniprot.org/citations/8268912 | http://purl.uniprot.org/core/author | "Raap A.K."xsd:string |
| http://purl.uniprot.org/citations/8268912 | http://purl.uniprot.org/core/author | "Wiegand J."xsd:string |
| http://purl.uniprot.org/citations/8268912 | http://purl.uniprot.org/core/author | "Wiegand J."xsd:string |
| http://purl.uniprot.org/citations/8268912 | http://purl.uniprot.org/core/author | "van Lohuizen M."xsd:string |
| http://purl.uniprot.org/citations/8268912 | http://purl.uniprot.org/core/author | "van Lohuizen M."xsd:string |
| http://purl.uniprot.org/citations/8268912 | http://purl.uniprot.org/core/date | "1993"xsd:gYear |
| http://purl.uniprot.org/citations/8268912 | http://purl.uniprot.org/core/date | "1993"xsd:gYear |
| http://purl.uniprot.org/citations/8268912 | http://purl.uniprot.org/core/name | "Hum. Mol. Genet."xsd:string |
| http://purl.uniprot.org/citations/8268912 | http://purl.uniprot.org/core/name | "Hum. Mol. Genet."xsd:string |
| http://purl.uniprot.org/citations/8268912 | http://purl.uniprot.org/core/pages | "1597-1603"xsd:string |
| http://purl.uniprot.org/citations/8268912 | http://purl.uniprot.org/core/pages | "1597-1603"xsd:string |
| http://purl.uniprot.org/citations/8268912 | http://purl.uniprot.org/core/title | "Characterization and chromosomal localization of the human proto-oncogene BMI-1."xsd:string |
| http://purl.uniprot.org/citations/8268912 | http://purl.uniprot.org/core/title | "Characterization and chromosomal localization of the human proto-oncogene BMI-1."xsd:string |
| http://purl.uniprot.org/citations/8268912 | http://purl.uniprot.org/core/volume | "2"xsd:string |
| http://purl.uniprot.org/citations/8268912 | http://purl.uniprot.org/core/volume | "2"xsd:string |