| http://purl.uniprot.org/citations/8274409 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8274409 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8274409 | http://www.w3.org/2000/01/rdf-schema#comment | "To investigate the structural abnormality of the androgen receptor (AR) in human prostate cancers, exons B-H encoding DNA- and hormone-binding domains were examined by single-strand conformation polymorphism analysis of polymerase chain reaction products using originally designed oligoprimers. Tissues from 7 cases of untreated stage B prostate cancer surgically removed and from 8 cases of endocrine therapy-resistant cancers obtained at autopsy were used in the study. Two different mutations were identified in exons D and H in the different cancer foci of the same cancer death patient. One mutation in exon D (at codon 701, Leu to His) was detected in the prostate, and the other in exon H (at codon 877, Thr to Ala) was found in metastatic tissues. In untreated cancer tissues and the other autopsy samples, no mutations were detected. The mutation in exon H was identical to that reported in LNCaP cells. These results indicate that AR gene mutations occur in relation to endocrine therapy-resistance, although the mutation was found in 1 out of 8 resistant cases (12.5%) at autopsy."xsd:string |
| http://purl.uniprot.org/citations/8274409 | http://purl.org/dc/terms/identifier | "doi:10.1016/0960-0760(93)90316-o"xsd:string |
| http://purl.uniprot.org/citations/8274409 | http://purl.org/dc/terms/identifier | "doi:10.1016/0960-0760(93)90316-o"xsd:string |
| http://purl.uniprot.org/citations/8274409 | http://purl.uniprot.org/core/author | "Sato N."xsd:string |
| http://purl.uniprot.org/citations/8274409 | http://purl.uniprot.org/core/author | "Sato N."xsd:string |
| http://purl.uniprot.org/citations/8274409 | http://purl.uniprot.org/core/author | "Suzuki H."xsd:string |
| http://purl.uniprot.org/citations/8274409 | http://purl.uniprot.org/core/author | "Suzuki H."xsd:string |
| http://purl.uniprot.org/citations/8274409 | http://purl.uniprot.org/core/author | "Seino S."xsd:string |
| http://purl.uniprot.org/citations/8274409 | http://purl.uniprot.org/core/author | "Seino S."xsd:string |
| http://purl.uniprot.org/citations/8274409 | http://purl.uniprot.org/core/author | "Masai M."xsd:string |
| http://purl.uniprot.org/citations/8274409 | http://purl.uniprot.org/core/author | "Masai M."xsd:string |
| http://purl.uniprot.org/citations/8274409 | http://purl.uniprot.org/core/author | "Shimazaki J."xsd:string |
| http://purl.uniprot.org/citations/8274409 | http://purl.uniprot.org/core/author | "Shimazaki J."xsd:string |
| http://purl.uniprot.org/citations/8274409 | http://purl.uniprot.org/core/author | "Watabe Y."xsd:string |
| http://purl.uniprot.org/citations/8274409 | http://purl.uniprot.org/core/author | "Watabe Y."xsd:string |
| http://purl.uniprot.org/citations/8274409 | http://purl.uniprot.org/core/date | "1993"xsd:gYear |
| http://purl.uniprot.org/citations/8274409 | http://purl.uniprot.org/core/date | "1993"xsd:gYear |
| http://purl.uniprot.org/citations/8274409 | http://purl.uniprot.org/core/name | "J. Steroid Biochem. Mol. Biol."xsd:string |
| http://purl.uniprot.org/citations/8274409 | http://purl.uniprot.org/core/name | "J. Steroid Biochem. Mol. Biol."xsd:string |
| http://purl.uniprot.org/citations/8274409 | http://purl.uniprot.org/core/pages | "759-765"xsd:string |
| http://purl.uniprot.org/citations/8274409 | http://purl.uniprot.org/core/pages | "759-765"xsd:string |
| http://purl.uniprot.org/citations/8274409 | http://purl.uniprot.org/core/title | "Androgen receptor gene mutations in human prostate cancer."xsd:string |
| http://purl.uniprot.org/citations/8274409 | http://purl.uniprot.org/core/title | "Androgen receptor gene mutations in human prostate cancer."xsd:string |