| http://purl.uniprot.org/citations/8276898 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8276898 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8276898 | http://www.w3.org/2000/01/rdf-schema#comment | "We show that the alpha-spectrin gene is essential for larval survival and development by characterizing several alpha-spectrin mutations in Drosophila. P-element minigene rescue and sequence analysis were used to identify the alpha-spectrin gene as the l(3)dre3 complementation group of the Dras-Roughened-ecdysoneless region of chromosome 3 (Sliter et al., 1988). Germ line transformants carrying an alpha-spectrin cDNA, whose expression is driven by the ubiquitin promoter, fully rescued the first to second instar lethality characteristic of the l(3)dre3 alleles. The molecular defects in two gamma-ray-induced alleles were identified. One of these mutations, which resulted in second instar lethality, contained a 73-bp deletion in alpha-spectrin segment 22 (starting at amino acid residue 2312), producing a premature stop codon between the two EF hands found in this segment. The second mutation, which resulted in first instar lethality, contained a 20 base pair deletion in the middle of segment 1 (at amino acid residue 92), resulting in a premature stop codon. Examination of the spectrin-deficient larvae revealed a loss of contact between epithelial cells of the gut and disruption of cell-substratum interactions. The most pronounced morphological change was seen in tissues of complex cellular architecture such as the middle midgut where a loss of cell contact between cup-shaped cuprophilic cells and neighboring interstitial cells was accompanied by disorganization of the cuprophilic cell brush borders. Our examination of spectrin deficient larvae suggests that an important role of non-erythroid spectrin is to stabilize cell to cell interactions that are critical for the maintenance of cell shape and subcellular organization within tissues."xsd:string |
| http://purl.uniprot.org/citations/8276898 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.123.6.1797"xsd:string |
| http://purl.uniprot.org/citations/8276898 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.123.6.1797"xsd:string |
| http://purl.uniprot.org/citations/8276898 | http://purl.uniprot.org/core/author | "Coyne R.S."xsd:string |
| http://purl.uniprot.org/citations/8276898 | http://purl.uniprot.org/core/author | "Coyne R.S."xsd:string |
| http://purl.uniprot.org/citations/8276898 | http://purl.uniprot.org/core/author | "Lee J.K."xsd:string |
| http://purl.uniprot.org/citations/8276898 | http://purl.uniprot.org/core/author | "Lee J.K."xsd:string |
| http://purl.uniprot.org/citations/8276898 | http://purl.uniprot.org/core/author | "Branton D."xsd:string |
| http://purl.uniprot.org/citations/8276898 | http://purl.uniprot.org/core/author | "Branton D."xsd:string |
| http://purl.uniprot.org/citations/8276898 | http://purl.uniprot.org/core/author | "Goldstein L.S.B."xsd:string |
| http://purl.uniprot.org/citations/8276898 | http://purl.uniprot.org/core/author | "Goldstein L.S.B."xsd:string |
| http://purl.uniprot.org/citations/8276898 | http://purl.uniprot.org/core/author | "Dubreuil R.R."xsd:string |
| http://purl.uniprot.org/citations/8276898 | http://purl.uniprot.org/core/author | "Dubreuil R.R."xsd:string |
| http://purl.uniprot.org/citations/8276898 | http://purl.uniprot.org/core/date | "1993"xsd:gYear |
| http://purl.uniprot.org/citations/8276898 | http://purl.uniprot.org/core/date | "1993"xsd:gYear |
| http://purl.uniprot.org/citations/8276898 | http://purl.uniprot.org/core/name | "J. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/8276898 | http://purl.uniprot.org/core/name | "J. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/8276898 | http://purl.uniprot.org/core/pages | "1797-1809"xsd:string |
| http://purl.uniprot.org/citations/8276898 | http://purl.uniprot.org/core/pages | "1797-1809"xsd:string |
| http://purl.uniprot.org/citations/8276898 | http://purl.uniprot.org/core/title | "Cell shape and interaction defects in alpha-spectrin mutants of Drosophila melanogaster."xsd:string |
| http://purl.uniprot.org/citations/8276898 | http://purl.uniprot.org/core/title | "Cell shape and interaction defects in alpha-spectrin mutants of Drosophila melanogaster."xsd:string |
| http://purl.uniprot.org/citations/8276898 | http://purl.uniprot.org/core/volume | "123"xsd:string |
| http://purl.uniprot.org/citations/8276898 | http://purl.uniprot.org/core/volume | "123"xsd:string |