| http://purl.uniprot.org/citations/8280757 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8280757 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8280757 | http://www.w3.org/2000/01/rdf-schema#comment | "TsTX-V, a new neurotoxin from Tityus serrulatus scorpion venom able to induce a prolongation of the inactivation of Na+ channels, has been purified to homogeneity. The venom was chromatographed on CM-cellulose-52 and 13 fractions were first collected. A subsequent stepwise elution chromatography of fraction XI afforded, among other toxins, highly purified TsTX-V, which showed a single band by PAGE, SDS-PAGE or isoelectric focusing, a distinctive amino acid composition, mol. wt. = 7230, pI = 8.0 and i.v. LD50 = 94 +/-7 micrograms/kg in mice. TsTX-V induced a long lasting hypertension in anesthetized rats and prolonged the action potential of the B fibers of the rabbit vagus nerve at 0.03 microgram/ml. At 0.3 microgram/ml and higher concentrations it caused also a nerve depolarization. These effects on nerve membranes were irreversible and could be suppressed by tetrodotoxin (200-500 nM). Nerve fibers depolarized by high extracellular K+(15-30mM) concentrations still displayed long duration action potentials after TsTX-V treatment. It is suggested that TsTX-V blocks the Na+ channel inactivation system probably as an alpha-toxin."xsd:string |
| http://purl.uniprot.org/citations/8280757 | http://purl.org/dc/terms/identifier | "doi:10.1016/0304-4165(94)90098-1"xsd:string |
| http://purl.uniprot.org/citations/8280757 | http://purl.org/dc/terms/identifier | "doi:10.1016/0304-4165(94)90098-1"xsd:string |
| http://purl.uniprot.org/citations/8280757 | http://purl.uniprot.org/core/author | "Giglio J.R."xsd:string |
| http://purl.uniprot.org/citations/8280757 | http://purl.uniprot.org/core/author | "Giglio J.R."xsd:string |
| http://purl.uniprot.org/citations/8280757 | http://purl.uniprot.org/core/author | "Vieira C.A."xsd:string |
| http://purl.uniprot.org/citations/8280757 | http://purl.uniprot.org/core/author | "Vieira C.A."xsd:string |
| http://purl.uniprot.org/citations/8280757 | http://purl.uniprot.org/core/author | "Arantes E.C."xsd:string |
| http://purl.uniprot.org/citations/8280757 | http://purl.uniprot.org/core/author | "Arantes E.C."xsd:string |
| http://purl.uniprot.org/citations/8280757 | http://purl.uniprot.org/core/author | "Sampaio S.V."xsd:string |
| http://purl.uniprot.org/citations/8280757 | http://purl.uniprot.org/core/author | "Sampaio S.V."xsd:string |
| http://purl.uniprot.org/citations/8280757 | http://purl.uniprot.org/core/author | "Riccioppo Neto F."xsd:string |
| http://purl.uniprot.org/citations/8280757 | http://purl.uniprot.org/core/author | "Riccioppo Neto F."xsd:string |
| http://purl.uniprot.org/citations/8280757 | http://purl.uniprot.org/core/date | "1994"xsd:gYear |
| http://purl.uniprot.org/citations/8280757 | http://purl.uniprot.org/core/date | "1994"xsd:gYear |
| http://purl.uniprot.org/citations/8280757 | http://purl.uniprot.org/core/name | "Biochim. Biophys. Acta"xsd:string |
| http://purl.uniprot.org/citations/8280757 | http://purl.uniprot.org/core/name | "Biochim. Biophys. Acta"xsd:string |
| http://purl.uniprot.org/citations/8280757 | http://purl.uniprot.org/core/pages | "69-75"xsd:string |
| http://purl.uniprot.org/citations/8280757 | http://purl.uniprot.org/core/pages | "69-75"xsd:string |
| http://purl.uniprot.org/citations/8280757 | http://purl.uniprot.org/core/title | "Isolation and characterization of TsTX-V, a new neurotoxin from Tityus serrulatus scorpion venom which delays the inactivation of Na+ channels."xsd:string |
| http://purl.uniprot.org/citations/8280757 | http://purl.uniprot.org/core/title | "Isolation and characterization of TsTX-V, a new neurotoxin from Tityus serrulatus scorpion venom which delays the inactivation of Na+ channels."xsd:string |
| http://purl.uniprot.org/citations/8280757 | http://purl.uniprot.org/core/volume | "1199"xsd:string |
| http://purl.uniprot.org/citations/8280757 | http://purl.uniprot.org/core/volume | "1199"xsd:string |