| http://purl.uniprot.org/citations/8294040 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8294040 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8294040 | http://www.w3.org/2000/01/rdf-schema#comment | "The genes necessary for the correctly regulated catabolism of quinate in Aspergillus nidulans and Neurospora crassa are controlled at the level of transcription by a DNA-binding activator protein and a repressor protein that directly interact with one another. The repressor protein is homologous throughout its length with the three C-terminal domains of a pentafunctional enzyme catalysing five consecutive steps in the related anabolic shikimate pathway. We now report that the activator protein is homologous to the two N-terminal domains of the same pentafunctional enzyme and that this proposed structural similarity suggests a molecular mechanism by which the repressor recognises the activator protein. We believe that this is the first report of the genesis of a pair of interacting eukaryotic regulatory proteins by the splitting of a multidomain anabolic enzyme. The recruitment of preformed enzymatically active domains to a regulatory role may represent a general mechanism for the evolution of pathway-specific regulator proteins in dispensable pathways."xsd:string |
| http://purl.uniprot.org/citations/8294040 | http://purl.org/dc/terms/identifier | "doi:10.1016/0378-1119(93)90446-a"xsd:string |
| http://purl.uniprot.org/citations/8294040 | http://purl.org/dc/terms/identifier | "doi:10.1016/0378-1119(93)90446-a"xsd:string |
| http://purl.uniprot.org/citations/8294040 | http://purl.uniprot.org/core/author | "Hawkins A.R."xsd:string |
| http://purl.uniprot.org/citations/8294040 | http://purl.uniprot.org/core/author | "Hawkins A.R."xsd:string |
| http://purl.uniprot.org/citations/8294040 | http://purl.uniprot.org/core/author | "Roberts C.F."xsd:string |
| http://purl.uniprot.org/citations/8294040 | http://purl.uniprot.org/core/author | "Roberts C.F."xsd:string |
| http://purl.uniprot.org/citations/8294040 | http://purl.uniprot.org/core/author | "Lamb H.K."xsd:string |
| http://purl.uniprot.org/citations/8294040 | http://purl.uniprot.org/core/author | "Lamb H.K."xsd:string |
| http://purl.uniprot.org/citations/8294040 | http://purl.uniprot.org/core/author | "Moore J.D."xsd:string |
| http://purl.uniprot.org/citations/8294040 | http://purl.uniprot.org/core/author | "Moore J.D."xsd:string |
| http://purl.uniprot.org/citations/8294040 | http://purl.uniprot.org/core/date | "1993"xsd:gYear |
| http://purl.uniprot.org/citations/8294040 | http://purl.uniprot.org/core/date | "1993"xsd:gYear |
| http://purl.uniprot.org/citations/8294040 | http://purl.uniprot.org/core/name | "Gene"xsd:string |
| http://purl.uniprot.org/citations/8294040 | http://purl.uniprot.org/core/name | "Gene"xsd:string |
| http://purl.uniprot.org/citations/8294040 | http://purl.uniprot.org/core/pages | "49-54"xsd:string |
| http://purl.uniprot.org/citations/8294040 | http://purl.uniprot.org/core/pages | "49-54"xsd:string |
| http://purl.uniprot.org/citations/8294040 | http://purl.uniprot.org/core/title | "Genesis of eukaryotic transcriptional activator and repressor proteins by splitting a multidomain anabolic enzyme."xsd:string |
| http://purl.uniprot.org/citations/8294040 | http://purl.uniprot.org/core/title | "Genesis of eukaryotic transcriptional activator and repressor proteins by splitting a multidomain anabolic enzyme."xsd:string |
| http://purl.uniprot.org/citations/8294040 | http://purl.uniprot.org/core/volume | "136"xsd:string |
| http://purl.uniprot.org/citations/8294040 | http://purl.uniprot.org/core/volume | "136"xsd:string |
| http://purl.uniprot.org/citations/8294040 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8294040 |
| http://purl.uniprot.org/citations/8294040 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8294040 |