| http://purl.uniprot.org/citations/8294403 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8294403 | http://www.w3.org/2000/01/rdf-schema#comment | "Binding of interleukin-2 (IL-2) to the IL-2 receptor (IL-2R) stimulates Src family kinases, tyrosine phosphorylation of several proteins, conversion of Ras to its active GTP-bound form, and eventually c-fos, c-jun, and c-myc induction. The IL-2R beta chain plays a crucial role in IL-2R signaling. Within the cytoplasmic domain of the beta chain, a region essential for mitogenesis and another involved in binding the Src family kinase Lck have been defined. The beta chain itself is tyrosine-phosphorylated upon IL-2 stimulation. Since the adapter protein Shc acts upstream of Ras and is involved in T cell receptor-mediated Ras activation, we examined the role of Shc in IL-2 signaling. Shc was found to be tyrosine-phosphorylated upon IL-2 stimulation in CTLL-20 cells. After its phosphorylation, Shc interacted with another adapter protein, Grb2, and, via Grb2, with the Ras GTP/GDP exchange factor mSOS. After IL-2 stimulation, Shc also associated with the IL-2R beta chain. Thus, during IL-2 signaling, the interaction of Shc with the IL-2R beta chain and its simultaneous association with Grb2 and mSOS may couple IL-2R stimulation to Ras signaling."xsd:string |
| http://purl.uniprot.org/citations/8294403 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0021-9258(17)42066-7"xsd:string |
| http://purl.uniprot.org/citations/8294403 | http://purl.uniprot.org/core/author | "Ravichandran K.S."xsd:string |
| http://purl.uniprot.org/citations/8294403 | http://purl.uniprot.org/core/author | "Burakoff S.J."xsd:string |
| http://purl.uniprot.org/citations/8294403 | http://purl.uniprot.org/core/date | "1994"xsd:gYear |
| http://purl.uniprot.org/citations/8294403 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/8294403 | http://purl.uniprot.org/core/pages | "1599-1602"xsd:string |
| http://purl.uniprot.org/citations/8294403 | http://purl.uniprot.org/core/title | "The adapter protein Shc interacts with the interleukin-2 (IL-2) receptor upon IL-2 stimulation."xsd:string |
| http://purl.uniprot.org/citations/8294403 | http://purl.uniprot.org/core/volume | "269"xsd:string |
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