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| http://purl.uniprot.org/citations/8297787 | http://www.w3.org/2000/01/rdf-schema#comment | "We investigated the rat brain for the presence and activation state of the inducible transcription factor NF-kappa B. Two forms of NF-kappa B containing the transactivating p65 subunit were found in all brain regions investigated. The majority of NF-kappa B was in an inducible cytoplasmic form by virtue of its association with the inhibitory subunit I kappa B. Significant amounts of inducible NF-kappa B forms were present in synaptosomes, as suggested by electrophoretic mobility shift assay and Western blot analysis of subcellular brain fractions. A synaptic localization of NF-kappa B was further evident from immunostaining of inner and outer plexiform layers of the retina with an antibody directed against the p50 subunit of NF-kappa B. In cerebral cortex and striatum, NF-kappa B-specific antibodies showed a punctate immunostaining partially overlapping with that for the synaptic marker protein synaptophysin. NF-kappa B is thus the first transcription factor found in synapses of neurons. With its unusual subneuronal localization, the inducible transcription factor has the potential to function as retrograde messenger mediating stimulus-response coupling and long-term changes in gene expression following presynaptic stimulation."xsd:string |
| http://purl.uniprot.org/citations/8297787 | http://purl.org/dc/terms/identifier | "doi:10.1016/0925-4773(93)90031-r"xsd:string |
| http://purl.uniprot.org/citations/8297787 | http://purl.uniprot.org/core/author | "Baeuerle P.A."xsd:string |
| http://purl.uniprot.org/citations/8297787 | http://purl.uniprot.org/core/author | "Kaltschmidt B."xsd:string |
| http://purl.uniprot.org/citations/8297787 | http://purl.uniprot.org/core/author | "Kaltschmidt C."xsd:string |
| http://purl.uniprot.org/citations/8297787 | http://purl.uniprot.org/core/date | "1993"xsd:gYear |
| http://purl.uniprot.org/citations/8297787 | http://purl.uniprot.org/core/name | "Mech Dev"xsd:string |
| http://purl.uniprot.org/citations/8297787 | http://purl.uniprot.org/core/pages | "135-147"xsd:string |
| http://purl.uniprot.org/citations/8297787 | http://purl.uniprot.org/core/title | "Brain synapses contain inducible forms of the transcription factor NF-kappa B."xsd:string |
| http://purl.uniprot.org/citations/8297787 | http://purl.uniprot.org/core/volume | "43"xsd:string |
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