| http://purl.uniprot.org/citations/8299935 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8299935 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8299935 | http://www.w3.org/2000/01/rdf-schema#comment | "The let-60 ras gene of Caenorhabditis elegans is one of the key players in a signal transduction pathway that controls the choice between vulval and epidermal differentiation in response to extracellular signals. To identify components acting downstream of let-60 ras in the vulval signaling pathway, we have identified a reduction-of-function mutation in the sur-1 gene that completely suppresses the multivulva phenotype of a hyperactive let-60 ras mutation. About 10% of animals homozygous for the sur-1 mutation also display a specific and intriguing vulval cell lineage defect. In addition, the sur-1 mutation results in a cold-sensitive egg-laying defective phenotype and a partial larval lethal phenotype. We have cloned the sur-1 gene by DNA-mediated transformation and have shown that it encodes a protein similar in overall structure to mammalian MAP kinases (ERKs). The functional homology between Sur-1 MAP kinase and mammalian MAP kinases was also demonstrated by the ability of a rat ERK2 kinase to rescue the sur-1 mutant phenotypes. Genetic double-mutant analyses place sur-1 downstream of let-60 ras but upstream of lin-1 in the vulval signaling pathway. Our results provide further evidence for the extreme conservation of Ras-mediated signaling pathway between worms and humans and for the function of MAP kinases in cell signaling processes that control cell differentiation and animal development."xsd:string |
| http://purl.uniprot.org/citations/8299935 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.8.2.147"xsd:string |
| http://purl.uniprot.org/citations/8299935 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.8.2.147"xsd:string |
| http://purl.uniprot.org/citations/8299935 | http://purl.uniprot.org/core/author | "Han M."xsd:string |
| http://purl.uniprot.org/citations/8299935 | http://purl.uniprot.org/core/author | "Han M."xsd:string |
| http://purl.uniprot.org/citations/8299935 | http://purl.uniprot.org/core/author | "Wu Y."xsd:string |
| http://purl.uniprot.org/citations/8299935 | http://purl.uniprot.org/core/author | "Wu Y."xsd:string |
| http://purl.uniprot.org/citations/8299935 | http://purl.uniprot.org/core/date | "1994"xsd:gYear |
| http://purl.uniprot.org/citations/8299935 | http://purl.uniprot.org/core/date | "1994"xsd:gYear |
| http://purl.uniprot.org/citations/8299935 | http://purl.uniprot.org/core/name | "Genes Dev."xsd:string |
| http://purl.uniprot.org/citations/8299935 | http://purl.uniprot.org/core/name | "Genes Dev."xsd:string |
| http://purl.uniprot.org/citations/8299935 | http://purl.uniprot.org/core/pages | "147-159"xsd:string |
| http://purl.uniprot.org/citations/8299935 | http://purl.uniprot.org/core/pages | "147-159"xsd:string |
| http://purl.uniprot.org/citations/8299935 | http://purl.uniprot.org/core/title | "Suppression of activated Let-60 ras protein defines a role of Caenorhabditis elegans Sur-1 MAP kinase in vulval differentiation."xsd:string |
| http://purl.uniprot.org/citations/8299935 | http://purl.uniprot.org/core/title | "Suppression of activated Let-60 ras protein defines a role of Caenorhabditis elegans Sur-1 MAP kinase in vulval differentiation."xsd:string |
| http://purl.uniprot.org/citations/8299935 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/8299935 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/8299935 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8299935 |
| http://purl.uniprot.org/citations/8299935 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8299935 |
| http://purl.uniprot.org/citations/8299935 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/8299935 |
| http://purl.uniprot.org/citations/8299935 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/8299935 |
| http://purl.uniprot.org/uniprot/P39745 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/8299935 |
| http://purl.uniprot.org/uniprot/P39745#attribution-058AAA744D1CF60EB9AB9B146E754079 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/8299935 |