| http://purl.uniprot.org/citations/8299936 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8299936 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8299936 | http://www.w3.org/2000/01/rdf-schema#comment | "During development of the Caenorhabditis elegans hermaphrodite, the gonadal anchor cell induces nearby Pn.p cells to adopt vulval fates. The response to this signal is mediated by a receptor tyrosine kinase signal transduction pathway that has been remarkably well conserved during metazoan evolution. Because mitogen-activated protein (MAP) kinases are activated by receptor tyrosine kinase pathways in vertebrate cells, we hypothesized that C. elegans MAP kinase homologs may play a role in vulval induction. Two C. elegans MAP kinase genes, mpk-1 and mpk-2 (mpk, MAP kinase), were cloned using degenerate oligonucleotide primers and PCR amplification; in parallel, genes involved in vulval induction were identified by screening for mutations that suppress the vulval defects caused by an activated let-60 ras gene. One such suppressor mutation is an allele of mpk-1. We used a new type of mosaic analysis to show that mpk-1 acts cell autonomously in the Pn.p cells. Our results show that mpk-1 plays an important functional role as an activator in ras-mediated cell signaling in vivo."xsd:string |
| http://purl.uniprot.org/citations/8299936 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.8.2.160"xsd:string |
| http://purl.uniprot.org/citations/8299936 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.8.2.160"xsd:string |
| http://purl.uniprot.org/citations/8299936 | http://purl.uniprot.org/core/author | "Kim S.K."xsd:string |
| http://purl.uniprot.org/citations/8299936 | http://purl.uniprot.org/core/author | "Kim S.K."xsd:string |
| http://purl.uniprot.org/citations/8299936 | http://purl.uniprot.org/core/author | "Horvitz H.R."xsd:string |
| http://purl.uniprot.org/citations/8299936 | http://purl.uniprot.org/core/author | "Horvitz H.R."xsd:string |
| http://purl.uniprot.org/citations/8299936 | http://purl.uniprot.org/core/author | "Kornfeld K."xsd:string |
| http://purl.uniprot.org/citations/8299936 | http://purl.uniprot.org/core/author | "Kornfeld K."xsd:string |
| http://purl.uniprot.org/citations/8299936 | http://purl.uniprot.org/core/author | "Miller L.M."xsd:string |
| http://purl.uniprot.org/citations/8299936 | http://purl.uniprot.org/core/author | "Miller L.M."xsd:string |
| http://purl.uniprot.org/citations/8299936 | http://purl.uniprot.org/core/author | "Lackner M.R."xsd:string |
| http://purl.uniprot.org/citations/8299936 | http://purl.uniprot.org/core/author | "Lackner M.R."xsd:string |
| http://purl.uniprot.org/citations/8299936 | http://purl.uniprot.org/core/date | "1994"xsd:gYear |
| http://purl.uniprot.org/citations/8299936 | http://purl.uniprot.org/core/date | "1994"xsd:gYear |
| http://purl.uniprot.org/citations/8299936 | http://purl.uniprot.org/core/name | "Genes Dev."xsd:string |
| http://purl.uniprot.org/citations/8299936 | http://purl.uniprot.org/core/name | "Genes Dev."xsd:string |
| http://purl.uniprot.org/citations/8299936 | http://purl.uniprot.org/core/pages | "160-173"xsd:string |
| http://purl.uniprot.org/citations/8299936 | http://purl.uniprot.org/core/pages | "160-173"xsd:string |
| http://purl.uniprot.org/citations/8299936 | http://purl.uniprot.org/core/title | "A MAP kinase homolog, mpk-1, is involved in ras-mediated induction of vulval cell fates in Caenorhabditis elegans."xsd:string |
| http://purl.uniprot.org/citations/8299936 | http://purl.uniprot.org/core/title | "A MAP kinase homolog, mpk-1, is involved in ras-mediated induction of vulval cell fates in Caenorhabditis elegans."xsd:string |
| http://purl.uniprot.org/citations/8299936 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/8299936 | http://purl.uniprot.org/core/volume | "8"xsd:string |