| http://purl.uniprot.org/citations/8318539 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8318539 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8318539 | http://www.w3.org/2000/01/rdf-schema#comment | "Platelet-derived growth factor (PDGF) consists of two chains, PDGF-A and -B, which activate as homo- or heterodimers two receptors, alpha and beta. To test PDGF function in vivo we have generated neutralizing monoclonal antibodies. When analyzed with rat PDGFs only antibodies raised against human PDGF-AA showed cross-species activity. This correlated with complete amino acid sequence conservation of PDGF-A whereas rat PDGF-B differed in six positions when cloned rat PDGF cDNAs were compared with their human homologs within the receptor binding region. Extracellular domains of cloned rat PDGF alpha- and beta-receptor cDNAs did not reflect this difference in cross-species ligand conservation. When rat extracellular domains were expressed as soluble proteins they bound human PDGF-BB with high affinity after immobilization of the purified proteins on solid phase. Dissociation constants were identical to those of their human homologs. Thus, high affinity binding of human PDGF-BB to extracellular domains does not depend on species origin but only on receptor type."xsd:string |
| http://purl.uniprot.org/citations/8318539 | http://purl.org/dc/terms/identifier | "doi:10.1016/0167-4781(93)90127-y"xsd:string |
| http://purl.uniprot.org/citations/8318539 | http://purl.org/dc/terms/identifier | "doi:10.1016/0167-4781(93)90127-y"xsd:string |
| http://purl.uniprot.org/citations/8318539 | http://purl.uniprot.org/core/author | "Pech M."xsd:string |
| http://purl.uniprot.org/citations/8318539 | http://purl.uniprot.org/core/author | "Pech M."xsd:string |
| http://purl.uniprot.org/citations/8318539 | http://purl.uniprot.org/core/author | "Herren B."xsd:string |
| http://purl.uniprot.org/citations/8318539 | http://purl.uniprot.org/core/author | "Herren B."xsd:string |
| http://purl.uniprot.org/citations/8318539 | http://purl.uniprot.org/core/author | "Weyer K.A."xsd:string |
| http://purl.uniprot.org/citations/8318539 | http://purl.uniprot.org/core/author | "Weyer K.A."xsd:string |
| http://purl.uniprot.org/citations/8318539 | http://purl.uniprot.org/core/author | "Loetscher P."xsd:string |
| http://purl.uniprot.org/citations/8318539 | http://purl.uniprot.org/core/author | "Loetscher P."xsd:string |
| http://purl.uniprot.org/citations/8318539 | http://purl.uniprot.org/core/author | "Rouge M."xsd:string |
| http://purl.uniprot.org/citations/8318539 | http://purl.uniprot.org/core/author | "Rouge M."xsd:string |
| http://purl.uniprot.org/citations/8318539 | http://purl.uniprot.org/core/date | "1993"xsd:gYear |
| http://purl.uniprot.org/citations/8318539 | http://purl.uniprot.org/core/date | "1993"xsd:gYear |
| http://purl.uniprot.org/citations/8318539 | http://purl.uniprot.org/core/name | "Biochim. Biophys. Acta"xsd:string |
| http://purl.uniprot.org/citations/8318539 | http://purl.uniprot.org/core/name | "Biochim. Biophys. Acta"xsd:string |
| http://purl.uniprot.org/citations/8318539 | http://purl.uniprot.org/core/pages | "294-302"xsd:string |
| http://purl.uniprot.org/citations/8318539 | http://purl.uniprot.org/core/pages | "294-302"xsd:string |
| http://purl.uniprot.org/citations/8318539 | http://purl.uniprot.org/core/title | "Conservation in sequence and affinity of human and rodent PDGF ligands and receptors."xsd:string |
| http://purl.uniprot.org/citations/8318539 | http://purl.uniprot.org/core/title | "Conservation in sequence and affinity of human and rodent PDGF ligands and receptors."xsd:string |
| http://purl.uniprot.org/citations/8318539 | http://purl.uniprot.org/core/volume | "1173"xsd:string |
| http://purl.uniprot.org/citations/8318539 | http://purl.uniprot.org/core/volume | "1173"xsd:string |