| http://purl.uniprot.org/citations/8356051 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8356051 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8356051 | http://www.w3.org/2000/01/rdf-schema#comment | "Vascular endothelial growth factor (VEGF), also known as vascular permeability factor, induces endothelial proliferation in vitro and vascular permeability in vivo. The human transmembrane c-fms-like tyrosine kinase Flt-1 has recently been identified as a VEGF receptor. Flt-1 kinase has seven immunoglobulin-like extracellular domains and a kinase insert sequence, features shared by two other human gene-encoded proteins, kinase insert domain-containing receptor (KDR) and FLT-4. In this study we show that the mouse homologue of KDR, Flk-1, is a second functional VEGF receptor. Flk-1 binds VEGF with high affinity, undergoes autophosphorylation, and mediates VEGF-dependent Ca2+ efflux in Xenopus oocytes injected with Flk-1 mRNA. We also demonstrate by in situ hybridization that Flk-1 protein expression in the mouse embryo is restricted to the vascular endothelium and the umbilical cord stroma. VEGF and its receptors Flk-1/KDR and Flt-1 may play a role in vascular development and regulation of vascular permeability."xsd:string |
| http://purl.uniprot.org/citations/8356051 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.90.16.7533"xsd:string |
| http://purl.uniprot.org/citations/8356051 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.90.16.7533"xsd:string |
| http://purl.uniprot.org/citations/8356051 | http://purl.uniprot.org/core/author | "Williams L.T."xsd:string |
| http://purl.uniprot.org/citations/8356051 | http://purl.uniprot.org/core/author | "Williams L.T."xsd:string |
| http://purl.uniprot.org/citations/8356051 | http://purl.uniprot.org/core/author | "Ferrara N."xsd:string |
| http://purl.uniprot.org/citations/8356051 | http://purl.uniprot.org/core/author | "Ferrara N."xsd:string |
| http://purl.uniprot.org/citations/8356051 | http://purl.uniprot.org/core/author | "Peters K.G."xsd:string |
| http://purl.uniprot.org/citations/8356051 | http://purl.uniprot.org/core/author | "Peters K.G."xsd:string |
| http://purl.uniprot.org/citations/8356051 | http://purl.uniprot.org/core/author | "de Vries C."xsd:string |
| http://purl.uniprot.org/citations/8356051 | http://purl.uniprot.org/core/author | "de Vries C."xsd:string |
| http://purl.uniprot.org/citations/8356051 | http://purl.uniprot.org/core/author | "Quinn T.P."xsd:string |
| http://purl.uniprot.org/citations/8356051 | http://purl.uniprot.org/core/author | "Quinn T.P."xsd:string |
| http://purl.uniprot.org/citations/8356051 | http://purl.uniprot.org/core/date | "1993"xsd:gYear |
| http://purl.uniprot.org/citations/8356051 | http://purl.uniprot.org/core/date | "1993"xsd:gYear |
| http://purl.uniprot.org/citations/8356051 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/8356051 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/8356051 | http://purl.uniprot.org/core/pages | "7533-7537"xsd:string |
| http://purl.uniprot.org/citations/8356051 | http://purl.uniprot.org/core/pages | "7533-7537"xsd:string |
| http://purl.uniprot.org/citations/8356051 | http://purl.uniprot.org/core/title | "Fetal liver kinase 1 is a receptor for vascular endothelial growth factor and is selectively expressed in vascular endothelium."xsd:string |
| http://purl.uniprot.org/citations/8356051 | http://purl.uniprot.org/core/title | "Fetal liver kinase 1 is a receptor for vascular endothelial growth factor and is selectively expressed in vascular endothelium."xsd:string |
| http://purl.uniprot.org/citations/8356051 | http://purl.uniprot.org/core/volume | "90"xsd:string |
| http://purl.uniprot.org/citations/8356051 | http://purl.uniprot.org/core/volume | "90"xsd:string |