| http://purl.uniprot.org/citations/8371983 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8371983 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8371983 | http://www.w3.org/2000/01/rdf-schema#comment | "While searching for a human homolog of the S.cerevisiae splicing factor PRP18, we found a polypeptide that reacted strongly with antibodies against PRP18. We purified this polypeptide from HeLa cells using a Western blot assay, and named it p54nrb (for nuclear RNA-binding protein, 54 kDa). cDNAs encoding p54nrb were cloned with probes derived from partial sequence of the purified protein. These cDNAs have identical coding sequences but differ as a result of alternative splicing in the 5' untranslated region. The cDNAs encode a 471 aa polypeptide that contains two RNA recognition motifs (RRMs). Human p54nrb has no homology to yeast PRP18, except for a common epitope, but is instead 71% identical to human splicing factor PSF within a 320 aa region that includes both RRMs. In addition, both p54nrb and PSF are rich in Pro and Gln residues outside the main homology region. The Drosophila puff-specific protein BJ6, one of three products encoded by the alternatively spliced no-on-transient A gene (nonA), which is required for normal vision and courtship song, is 42% identical to p54nrb in the same 320 aa region. The striking homology between p54nrb, PSF, and NONA/BJ6 defines a novel phylogenetically conserved protein segment, termed DBHS domain (for Drosophila behavior, human splicing), which may be involved in regulating diverse pathways at the level of pre-mRNA splicing."xsd:string |
| http://purl.uniprot.org/citations/8371983 | http://purl.org/dc/terms/identifier | "doi:10.1093/nar/21.17.4085"xsd:string |
| http://purl.uniprot.org/citations/8371983 | http://purl.org/dc/terms/identifier | "doi:10.1093/nar/21.17.4085"xsd:string |
| http://purl.uniprot.org/citations/8371983 | http://purl.uniprot.org/core/author | "Dong B."xsd:string |
| http://purl.uniprot.org/citations/8371983 | http://purl.uniprot.org/core/author | "Dong B."xsd:string |
| http://purl.uniprot.org/citations/8371983 | http://purl.uniprot.org/core/author | "Kobayashi R."xsd:string |
| http://purl.uniprot.org/citations/8371983 | http://purl.uniprot.org/core/author | "Kobayashi R."xsd:string |
| http://purl.uniprot.org/citations/8371983 | http://purl.uniprot.org/core/author | "Krainer A.R."xsd:string |
| http://purl.uniprot.org/citations/8371983 | http://purl.uniprot.org/core/author | "Krainer A.R."xsd:string |
| http://purl.uniprot.org/citations/8371983 | http://purl.uniprot.org/core/author | "Horowitz D.S."xsd:string |
| http://purl.uniprot.org/citations/8371983 | http://purl.uniprot.org/core/author | "Horowitz D.S."xsd:string |
| http://purl.uniprot.org/citations/8371983 | http://purl.uniprot.org/core/date | "1993"xsd:gYear |
| http://purl.uniprot.org/citations/8371983 | http://purl.uniprot.org/core/date | "1993"xsd:gYear |
| http://purl.uniprot.org/citations/8371983 | http://purl.uniprot.org/core/name | "Nucleic Acids Res."xsd:string |
| http://purl.uniprot.org/citations/8371983 | http://purl.uniprot.org/core/name | "Nucleic Acids Res."xsd:string |
| http://purl.uniprot.org/citations/8371983 | http://purl.uniprot.org/core/pages | "4085-4092"xsd:string |
| http://purl.uniprot.org/citations/8371983 | http://purl.uniprot.org/core/pages | "4085-4092"xsd:string |
| http://purl.uniprot.org/citations/8371983 | http://purl.uniprot.org/core/title | "Purification and cDNA cloning of HeLa cell p54nrb, a nuclear protein with two RNA recognition motifs and extensive homology to human splicing factor PSF and Drosophila NONA/BJ6."xsd:string |
| http://purl.uniprot.org/citations/8371983 | http://purl.uniprot.org/core/title | "Purification and cDNA cloning of HeLa cell p54nrb, a nuclear protein with two RNA recognition motifs and extensive homology to human splicing factor PSF and Drosophila NONA/BJ6."xsd:string |
| http://purl.uniprot.org/citations/8371983 | http://purl.uniprot.org/core/volume | "21"xsd:string |
| http://purl.uniprot.org/citations/8371983 | http://purl.uniprot.org/core/volume | "21"xsd:string |
| http://purl.uniprot.org/citations/8371983 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8371983 |
| http://purl.uniprot.org/citations/8371983 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/8371983 |