| http://purl.uniprot.org/citations/8373557 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8373557 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/8373557 | http://www.w3.org/2000/01/rdf-schema#comment | "A cDNA encoding the human brain vesicular monoamine transporter (VMT) was isolated and sequenced using PCR. The cDNA contains an open reading frame encoding a hydrophobic polypeptide of 514 amino acids with twelve membrane spanning segments, a calculated molecular weight of 55,709 Da, and an estimated isoelectrical point of 5.62. A structurally identical transporter is expressed in human platelets. Two intraplasmatic consensus phosphorylation sites of cAMP-dependent protein kinase recognition and two potential protein kinase C phosphorylation sites may be central to the regulation of the VMT. Although the human brain VMT is 90.7% homologous to the rat protein, an extensive sequence divergence occurs in the large luminal loop located between the first two transmembrane domains. This loop displays a remarkably reduced homology of 64.0% with several deletions and insertions, although four putative glycosylation sites are conserved. Since functional vesicular monoamine transport suppresses MPP+ toxicity and sequence divergence in the large luminal loop of the VMT expressed in rat brain and adrenal medulla may play a role in differential neurotoxic effects of MPP+, our findings indicate one possible molecular basis for the substantial species differences in the susceptibility to MPP+ demonstrated among humans, non-human primates, and rodents. They are also likely to facilitate molecular pharmacologic and genetic investigations of the human VMT in neurodegenerative disorders."xsd:string |
| http://purl.uniprot.org/citations/8373557 | http://purl.org/dc/terms/identifier | "doi:10.1007/bf01244941"xsd:string |
| http://purl.uniprot.org/citations/8373557 | http://purl.org/dc/terms/identifier | "doi:10.1007/bf01244941"xsd:string |
| http://purl.uniprot.org/citations/8373557 | http://purl.uniprot.org/core/author | "Gross J."xsd:string |
| http://purl.uniprot.org/citations/8373557 | http://purl.uniprot.org/core/author | "Gross J."xsd:string |
| http://purl.uniprot.org/citations/8373557 | http://purl.uniprot.org/core/author | "Murphy D.L."xsd:string |
| http://purl.uniprot.org/citations/8373557 | http://purl.uniprot.org/core/author | "Murphy D.L."xsd:string |
| http://purl.uniprot.org/citations/8373557 | http://purl.uniprot.org/core/author | "Lesch K.P."xsd:string |
| http://purl.uniprot.org/citations/8373557 | http://purl.uniprot.org/core/author | "Lesch K.P."xsd:string |
| http://purl.uniprot.org/citations/8373557 | http://purl.uniprot.org/core/author | "Riederer P."xsd:string |
| http://purl.uniprot.org/citations/8373557 | http://purl.uniprot.org/core/author | "Riederer P."xsd:string |
| http://purl.uniprot.org/citations/8373557 | http://purl.uniprot.org/core/author | "Wolozin B.L."xsd:string |
| http://purl.uniprot.org/citations/8373557 | http://purl.uniprot.org/core/author | "Wolozin B.L."xsd:string |
| http://purl.uniprot.org/citations/8373557 | http://purl.uniprot.org/core/date | "1993"xsd:gYear |
| http://purl.uniprot.org/citations/8373557 | http://purl.uniprot.org/core/date | "1993"xsd:gYear |
| http://purl.uniprot.org/citations/8373557 | http://purl.uniprot.org/core/name | "J. Neural Transm."xsd:string |
| http://purl.uniprot.org/citations/8373557 | http://purl.uniprot.org/core/name | "J. Neural Transm."xsd:string |
| http://purl.uniprot.org/citations/8373557 | http://purl.uniprot.org/core/pages | "75-82"xsd:string |
| http://purl.uniprot.org/citations/8373557 | http://purl.uniprot.org/core/pages | "75-82"xsd:string |
| http://purl.uniprot.org/citations/8373557 | http://purl.uniprot.org/core/title | "Extensive sequence divergence between the human and rat brain vesicular monoamine transporter: possible molecular basis for species differences in the susceptibility to MPP+."xsd:string |
| http://purl.uniprot.org/citations/8373557 | http://purl.uniprot.org/core/title | "Extensive sequence divergence between the human and rat brain vesicular monoamine transporter: possible molecular basis for species differences in the susceptibility to MPP+."xsd:string |
| http://purl.uniprot.org/citations/8373557 | http://purl.uniprot.org/core/volume | "93"xsd:string |
| http://purl.uniprot.org/citations/8373557 | http://purl.uniprot.org/core/volume | "93"xsd:string |